Lin Niu, Chinese Acad Sci, Chinese Academy of Sciences, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety
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Lei Liu, Chinese Acad Sci, Chinese Academy of Sciences, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Institute for Advanced Materials, Jiangsu University, Denmark
Meng Xu, Chinese Acad Sci, Chinese Academy of Sciences, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety
In this work we report the effect of terminus molecular modulators on the secondary structures of the amyloid peptide aggregates. The controlled modulation of the assembly structure and the transformation of beta-sheet secondary structures could be beneficial for gaining insight into the aggregation mechanism of peptides. Particularly, multiple assembling characteristics have been identified as a reflection of peptide-organic interactions.