Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing

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  • V. Palombo, Università degli studi del Molise
  • ,
  • J. J. Loor, University of Illinois at Urbana-Champaign
  • ,
  • M. D'Andrea, Università degli studi del Molise
  • ,
  • M. Vailati-Riboni, University of Illinois at Urbana-Champaign
  • ,
  • K. Shahzad, University of Illinois at Urbana-Champaign
  • ,
  • Uffe Krogh
  • P. K. Theil
Colostrum and milk are essential sources of antibodies and nutrients for the neonate, playing a key role in their survival and growth. Slight abnormalities in the timing of colostrogenesis/lactogenesis potentially threaten piglet survival. To further delineate the genes and transcription regulators implicated in the control of the transition from colostrogenesis to lactogenesis, we applied RNA-seq analysis of swine mammary gland tissue from late-gestation to farrowing. Three 2nd parity sows were used for mammary tissue biopsies on days 14, 10, 6 and 2 before (−) parturition and on day 1 after (+) parturition. A total of 15 mRNA libraries were sequenced on a HiSeq2500 (Illumina Inc.). The Dynamic Impact Approach and the Ingenuity Pathway Analysis were used for pathway analysis and gene network analysis, respectively.
Original languageEnglish
Article number322
JournalBMC Genomics
Volume19
Issue1
ISSN1471-2164
DOIs
Publication statusPublished - 3 May 2018

    Research areas

  • Colostrum, Mammary gland, Sow, Transcriptomics

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