Trafficking of B cell antigen in lymph nodes

Santiago F. Gonzalez; Søren Egedal Degn; Lisa A. Pitcher; Matthew Woodruff; Balthasar A. Heesters; Michael C. Carroll

Trafficking of B cell antigen in lymph nodes

Santiago F. Gonzalez, Søren Egedal Degn, Lisa A. Pitcher, Matthew Woodruff, Balthasar A. Heesters, Michael C. Carroll

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

121 Citations (Scopus)

Abstract

The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.

Translated title of the contribution	Transport af B celle antigen i lymfeknuder
Original language	English
Journal	Annual Review of Immunology
Volume	29
Pages (from-to)	215-233
Number of pages	19
ISSN	0732-0582
Publication status	Published - 2011

Cite this

@article{db2b5ed1fe7545c6ad3543cf95a45d7f,

title = "Trafficking of B cell antigen in lymph nodes",

abstract = "The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.",

author = "Gonzalez, {Santiago F.} and Degn, {S{\o}ren Egedal} and Pitcher, {Lisa A.} and Matthew Woodruff and Heesters, {Balthasar A.} and Carroll, {Michael C.}",

year = "2011",

language = "English",

volume = "29",

pages = "215--233",

journal = "Annual Review of Immunology",

issn = "0732-0582",

publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Trafficking of B cell antigen in lymph nodes

AU - Gonzalez, Santiago F.

AU - Degn, Søren Egedal

AU - Pitcher, Lisa A.

AU - Woodruff, Matthew

AU - Heesters, Balthasar A.

AU - Carroll, Michael C.

PY - 2011

Y1 - 2011

N2 - The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.

AB - The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.

M3 - Journal article

SN - 0732-0582

VL - 29

SP - 215

EP - 233

JO - Annual Review of Immunology

JF - Annual Review of Immunology

ER -