Traditional and Non-traditional Risk Factors for Osteoporosis in CKD

TY - JOUR

T1 - Traditional and Non-traditional Risk Factors for Osteoporosis in CKD

AU - Jørgensen, Hanne Skou

AU - David, Karel

AU - Salam, Syazrah

AU - Evenepoel, Pieter

AU - the European Renal Osteodystrophy (EUROD) workgroup, an initiative of the CKD-MBD working group of the ERA-EDTA

N1 - Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

PY - 2021/4

Y1 - 2021/4

N2 - Osteoporosis is a state of bone fragility with reduced skeletal resistance to trauma, and consequently increased risk of fracture. A wide range of conditions, including traditional risk factors, lifestyle choices, diseases and their treatments may contribute to bone fragility. It is therefore not surprising that the multi-morbid patient with chronic kidney disease (CKD) is at a particularly high risk. CKD is associated with reduced bone quantity, as well as impaired bone quality. Bone fragility in CKD is a composite of primary osteoporosis, accumulation of traditional and uremia-related risk factors, assaults brought on by systemic disease, and detrimental effects of drugs. Some risk factors are modifiable and represent potential targets for intervention. This review provides an overview of the heterogeneity of bone fragility in CKD.

AB - Osteoporosis is a state of bone fragility with reduced skeletal resistance to trauma, and consequently increased risk of fracture. A wide range of conditions, including traditional risk factors, lifestyle choices, diseases and their treatments may contribute to bone fragility. It is therefore not surprising that the multi-morbid patient with chronic kidney disease (CKD) is at a particularly high risk. CKD is associated with reduced bone quantity, as well as impaired bone quality. Bone fragility in CKD is a composite of primary osteoporosis, accumulation of traditional and uremia-related risk factors, assaults brought on by systemic disease, and detrimental effects of drugs. Some risk factors are modifiable and represent potential targets for intervention. This review provides an overview of the heterogeneity of bone fragility in CKD.

KW - Bone density

KW - Chronic kidney disease—mineral and bone disorder

KW - Chronic renal insufficiency

KW - Fracture

KW - Kidney transplantation

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=85101478626&partnerID=8YFLogxK

U2 - 10.1007/s00223-020-00786-0

DO - 10.1007/s00223-020-00786-0

M3 - Review

C2 - 33586002

AN - SCOPUS:85101478626

SN - 0171-967X

VL - 108

SP - 496

EP - 511

JO - Calcified Tissue International

JF - Calcified Tissue International

IS - 4

ER -