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TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs

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A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in four brain circuits receiving known sensory inputs. This strategy, as demonstrated here, accurately identifies these inputs.

Original languageEnglish
Article number114
JournalFrontiers in Cellular Neuroscience
Publication statusPublished - May 2020

    Research areas

  • innate fear, mouse behavior, neural circuits, optogenetics, viral tracing

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ID: 189813797