Towards fair and clinically relevant polygenic predictions

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Abstract

Lennon et al. recently proposed a clinical polygenic score (PGS) pipeline as part of the Electronic Medical Records and Genomics (eMERGE) network initiative. In this spotlight article we discuss the broader context for the use of PGS in preventive medicine and highlight key limitations and challenges facing their inclusion in prediction models.

Original languageEnglish
JournalTrends in Genetics
Volume40
Issue5
Pages (from-to)379-380
Number of pages2
ISSN0168-9525
DOIs
Publication statusPublished - May 2024

Keywords

  • clinical risk assessment
  • diverse ancestry
  • polygenic scores
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genomics
  • Humans
  • Preventive Medicine
  • Multifactorial Inheritance/genetics
  • Electronic Health Records

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