Time matters: Early-phase multiple sclerosis is accompanied by considerable impairments across multiple domains

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Time matters : Early-phase multiple sclerosis is accompanied by considerable impairments across multiple domains. / Thrue, C; Riemenschneider, Morten; Hvid, Lars Næsby; Stenager, E; Dalgas, Ulrik.

In: Multiple sclerosis (Houndmills, Basingstoke, England), 07.2020.

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@article{42c2bdae82404b2fb555046d54488d82,
title = "Time matters: Early-phase multiple sclerosis is accompanied by considerable impairments across multiple domains",
abstract = "Impairments across multiple domains are a disabling consequence of multiple sclerosis (MS). Originating from preventive medical strategies, the {"}time matters{"}-perspective has become a focal point when treating MS. In particular, early detection of physical and cognitive deficits, along with deficits in patient-reported outcomes seems crucial to further optimize both pharmacological and non-pharmacological MS treatment strategies. Therefore, this topical review investigates the level of impairments across multiple domains (physical function, cognitive function, and patient-reported outcomes) in the early stage of MS (⩽5 years since diagnosis, including clinically isolated syndrome (CIS)), when compared to matched healthy controls. Even at early disease stages, studies show impairments corresponding to 8%-34% and small-to-large numerical effect sizes (0.35-2.85) in MS/CIS patients across domains. This evidence call for early screening programs along with early interventions targeting the multiple impaired domains. This further highlights the importance of preventive initiatives preserving and/or restoring physical and cognitive reserve capacity if possible.",
keywords = "Rehabilitation, cognitive performance, deficits, early treatment, functional capacity",
author = "C Thrue and Morten Riemenschneider and Hvid, {Lars N{\ae}sby} and E Stenager and Ulrik Dalgas",
year = "2020",
month = jul,
doi = "10.1177/1352458520936231",
language = "English",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",

}

RIS

TY - JOUR

T1 - Time matters

T2 - Early-phase multiple sclerosis is accompanied by considerable impairments across multiple domains

AU - Thrue, C

AU - Riemenschneider, Morten

AU - Hvid, Lars Næsby

AU - Stenager, E

AU - Dalgas, Ulrik

PY - 2020/7

Y1 - 2020/7

N2 - Impairments across multiple domains are a disabling consequence of multiple sclerosis (MS). Originating from preventive medical strategies, the "time matters"-perspective has become a focal point when treating MS. In particular, early detection of physical and cognitive deficits, along with deficits in patient-reported outcomes seems crucial to further optimize both pharmacological and non-pharmacological MS treatment strategies. Therefore, this topical review investigates the level of impairments across multiple domains (physical function, cognitive function, and patient-reported outcomes) in the early stage of MS (⩽5 years since diagnosis, including clinically isolated syndrome (CIS)), when compared to matched healthy controls. Even at early disease stages, studies show impairments corresponding to 8%-34% and small-to-large numerical effect sizes (0.35-2.85) in MS/CIS patients across domains. This evidence call for early screening programs along with early interventions targeting the multiple impaired domains. This further highlights the importance of preventive initiatives preserving and/or restoring physical and cognitive reserve capacity if possible.

AB - Impairments across multiple domains are a disabling consequence of multiple sclerosis (MS). Originating from preventive medical strategies, the "time matters"-perspective has become a focal point when treating MS. In particular, early detection of physical and cognitive deficits, along with deficits in patient-reported outcomes seems crucial to further optimize both pharmacological and non-pharmacological MS treatment strategies. Therefore, this topical review investigates the level of impairments across multiple domains (physical function, cognitive function, and patient-reported outcomes) in the early stage of MS (⩽5 years since diagnosis, including clinically isolated syndrome (CIS)), when compared to matched healthy controls. Even at early disease stages, studies show impairments corresponding to 8%-34% and small-to-large numerical effect sizes (0.35-2.85) in MS/CIS patients across domains. This evidence call for early screening programs along with early interventions targeting the multiple impaired domains. This further highlights the importance of preventive initiatives preserving and/or restoring physical and cognitive reserve capacity if possible.

KW - Rehabilitation

KW - cognitive performance

KW - deficits

KW - early treatment

KW - functional capacity

UR - http://www.scopus.com/inward/record.url?scp=85087429531&partnerID=8YFLogxK

U2 - 10.1177/1352458520936231

DO - 10.1177/1352458520936231

M3 - Review

C2 - 32613902

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

ER -