Thyroid [123I]MIBG uptake in Parkinson's disease and diabetes mellitus

Tatyana D. Fedorova; Karoline Knudsen; Thorsten K. Rasmussen; Jacob Horsager; Adjmal Nahimi; Casper Skjærbæk; Eva Schaeffer; Daniela Berg; Astrid J. Terkelsen; Per Borghammer

doi:10.1016/j.ibneur.2023.03.006

Thyroid [¹²³I]MIBG uptake in Parkinson's disease and diabetes mellitus

Tatyana D. Fedorova^*, Karoline Knudsen, Thorsten K. Rasmussen, Jacob Horsager, Adjmal Nahimi, Casper Skjærbæk, Eva Schaeffer, Daniela Berg, Astrid J. Terkelsen, Per Borghammer

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

Thyroid [¹²³I]MIBG uptake is proposed as a tool for differentiating between Parkinson's disease (PD) and diabetes mellitus (DM) on [¹²³I]MIBG scintigraphies since both patient groups show decreased cardiac uptake. One study compared thyroid [¹²³I]MIBG uptake in DM and PD patients and reported reduced [¹²³I]MIBG uptake only in the PD group. Here, we investigated thyroid [¹²³I]MIBG uptake in patients with PD and DM and found severely reduced thyroid [¹²³I]MIBG uptake in DM. Larger studies are needed to substantiate whether DM patients are more or less likely to exhibit decreased thyroid MIBG uptake compared to controls and PD patients.

Original language	English
Journal	IBRO Neuroscience Reports
Volume	14
Pages (from-to)	342-345
Number of pages	4
ISSN	2667-2421
DOIs	https://doi.org/10.1016/j.ibneur.2023.03.006
Publication status	Published - Jun 2023

Keywords

Diabetes mellitus
MIBG
Parkinson's disease
Scintigraphy
Thyroid gland

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10.1016/j.ibneur.2023.03.006Licence: CC BY-NC-ND

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title = "Thyroid [123I]MIBG uptake in Parkinson's disease and diabetes mellitus",

abstract = "Thyroid [123I]MIBG uptake is proposed as a tool for differentiating between Parkinson's disease (PD) and diabetes mellitus (DM) on [123I]MIBG scintigraphies since both patient groups show decreased cardiac uptake. One study compared thyroid [123I]MIBG uptake in DM and PD patients and reported reduced [123I]MIBG uptake only in the PD group. Here, we investigated thyroid [123I]MIBG uptake in patients with PD and DM and found severely reduced thyroid [123I]MIBG uptake in DM. Larger studies are needed to substantiate whether DM patients are more or less likely to exhibit decreased thyroid MIBG uptake compared to controls and PD patients.",

keywords = "Diabetes mellitus, MIBG, Parkinson's disease, Scintigraphy, Thyroid gland",

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year = "2023",

month = jun,

doi = "10.1016/j.ibneur.2023.03.006",

language = "English",

volume = "14",

pages = "342--345",

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T1 - Thyroid [123I]MIBG uptake in Parkinson's disease and diabetes mellitus

AU - Fedorova, Tatyana D.

AU - Knudsen, Karoline

AU - Rasmussen, Thorsten K.

AU - Horsager, Jacob

AU - Nahimi, Adjmal

AU - Skjærbæk, Casper

AU - Schaeffer, Eva

AU - Berg, Daniela

AU - Terkelsen, Astrid J.

AU - Borghammer, Per

PY - 2023/6

Y1 - 2023/6

N2 - Thyroid [123I]MIBG uptake is proposed as a tool for differentiating between Parkinson's disease (PD) and diabetes mellitus (DM) on [123I]MIBG scintigraphies since both patient groups show decreased cardiac uptake. One study compared thyroid [123I]MIBG uptake in DM and PD patients and reported reduced [123I]MIBG uptake only in the PD group. Here, we investigated thyroid [123I]MIBG uptake in patients with PD and DM and found severely reduced thyroid [123I]MIBG uptake in DM. Larger studies are needed to substantiate whether DM patients are more or less likely to exhibit decreased thyroid MIBG uptake compared to controls and PD patients.

AB - Thyroid [123I]MIBG uptake is proposed as a tool for differentiating between Parkinson's disease (PD) and diabetes mellitus (DM) on [123I]MIBG scintigraphies since both patient groups show decreased cardiac uptake. One study compared thyroid [123I]MIBG uptake in DM and PD patients and reported reduced [123I]MIBG uptake only in the PD group. Here, we investigated thyroid [123I]MIBG uptake in patients with PD and DM and found severely reduced thyroid [123I]MIBG uptake in DM. Larger studies are needed to substantiate whether DM patients are more or less likely to exhibit decreased thyroid MIBG uptake compared to controls and PD patients.

KW - Diabetes mellitus

KW - MIBG

KW - Parkinson's disease

KW - Scintigraphy

KW - Thyroid gland

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DO - 10.1016/j.ibneur.2023.03.006

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SN - 2667-2421

VL - 14

SP - 342

EP - 345

JO - IBRO Neuroscience Reports

JF - IBRO Neuroscience Reports

ER -

Thyroid [¹²³I]MIBG uptake in Parkinson's disease and diabetes mellitus

Abstract

Keywords

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