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Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Standard

Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing. / Chen, Jiatian; Huang, Zihang; Zhang, Hongqian et al.
In: Chemical Engineering Journal, Vol. 443, 136234, 09.2022.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Chen, J, Huang, Z, Zhang, H, Zhang, Z, Wang, D, Xia, D, Yang, C & Dong, M 2022, 'Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing', Chemical Engineering Journal, vol. 443, 136234. https://doi.org/10.1016/j.cej.2022.136234

APA

Chen, J., Huang, Z., Zhang, H., Zhang, Z., Wang, D., Xia, D., Yang, C., & Dong, M. (2022). Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing. Chemical Engineering Journal, 443, [136234]. https://doi.org/10.1016/j.cej.2022.136234

CBE

Chen J, Huang Z, Zhang H, Zhang Z, Wang D, Xia D, Yang C, Dong M. 2022. Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing. Chemical Engineering Journal. 443:Article 136234. https://doi.org/10.1016/j.cej.2022.136234

MLA

Chen, Jiatian et al. "Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing". Chemical Engineering Journal. 2022. 443. https://doi.org/10.1016/j.cej.2022.136234

Vancouver

Chen J, Huang Z, Zhang H, Zhang Z, Wang D, Xia D et al. Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing. Chemical Engineering Journal. 2022 Sept;443:136234. doi: 10.1016/j.cej.2022.136234

Author

Chen, Jiatian ; Huang, Zihang ; Zhang, Hongqian et al. / Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing. In: Chemical Engineering Journal. 2022 ; Vol. 443.

Bibtex

@article{b74214f0ad4d4c37bc92d6b3f9a934c3,
title = "Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing",
abstract = "Effective hemostasis, antibacterial, and anti-inflammation are essential for wound healing, which, however, are hampered by the structural deficiencies of traditional wound dressings. Herein, we prepared a three-dimensional (3D) layered nanofiber sponge (3D-AgMOF-CUR), where silver-metal organic framework (Ag-MOF) was grown in situ and curcumin (CUR) was loaded, to promote the wound healing by timely absorbing exudate at the wound site, accelerating hemostasis, as well as resisting bacteria growth and inflammation. Nanostructure, water absorption capacity, porosity, elasticity and tensile properties, and drug release in vitro of the 3D-AgMOF-CUR were systemically characterized. Its outstanding hemostasis and coagulation effect were demonstrated by in vitro coagulation and blood suction tests. Experimental results from CCK-8 assay, disk diffusion and bacterial co-culture methods further evidenced the fantastic antibacterial effect and good cytocompatibility of the 3D-AgMOF-CUR. In addition, its high wound healing efficiency was confirmed in vivo, as revealed by improved wound healing efficiency and significantly decreased scar area during the healing process of a wound infection model. This study demonstrated that the layered 3D nanofiber sponge could shed light on the clinical wound healing in the future.",
keywords = "3D nanofiber sponge, Ag-MOF, Antibacterial, Curcumin, Wound healing",
author = "Jiatian Chen and Zihang Huang and Hongqian Zhang and Zhongyang Zhang and Donghui Wang and Dan Xia and Chuanxu Yang and Mingdong Dong",
year = "2022",
month = sep,
doi = "10.1016/j.cej.2022.136234",
language = "English",
volume = "443",
journal = "Chemical Engineering Journal",
issn = "1385-8947",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing

AU - Chen, Jiatian

AU - Huang, Zihang

AU - Zhang, Hongqian

AU - Zhang, Zhongyang

AU - Wang, Donghui

AU - Xia, Dan

AU - Yang, Chuanxu

AU - Dong, Mingdong

PY - 2022/9

Y1 - 2022/9

N2 - Effective hemostasis, antibacterial, and anti-inflammation are essential for wound healing, which, however, are hampered by the structural deficiencies of traditional wound dressings. Herein, we prepared a three-dimensional (3D) layered nanofiber sponge (3D-AgMOF-CUR), where silver-metal organic framework (Ag-MOF) was grown in situ and curcumin (CUR) was loaded, to promote the wound healing by timely absorbing exudate at the wound site, accelerating hemostasis, as well as resisting bacteria growth and inflammation. Nanostructure, water absorption capacity, porosity, elasticity and tensile properties, and drug release in vitro of the 3D-AgMOF-CUR were systemically characterized. Its outstanding hemostasis and coagulation effect were demonstrated by in vitro coagulation and blood suction tests. Experimental results from CCK-8 assay, disk diffusion and bacterial co-culture methods further evidenced the fantastic antibacterial effect and good cytocompatibility of the 3D-AgMOF-CUR. In addition, its high wound healing efficiency was confirmed in vivo, as revealed by improved wound healing efficiency and significantly decreased scar area during the healing process of a wound infection model. This study demonstrated that the layered 3D nanofiber sponge could shed light on the clinical wound healing in the future.

AB - Effective hemostasis, antibacterial, and anti-inflammation are essential for wound healing, which, however, are hampered by the structural deficiencies of traditional wound dressings. Herein, we prepared a three-dimensional (3D) layered nanofiber sponge (3D-AgMOF-CUR), where silver-metal organic framework (Ag-MOF) was grown in situ and curcumin (CUR) was loaded, to promote the wound healing by timely absorbing exudate at the wound site, accelerating hemostasis, as well as resisting bacteria growth and inflammation. Nanostructure, water absorption capacity, porosity, elasticity and tensile properties, and drug release in vitro of the 3D-AgMOF-CUR were systemically characterized. Its outstanding hemostasis and coagulation effect were demonstrated by in vitro coagulation and blood suction tests. Experimental results from CCK-8 assay, disk diffusion and bacterial co-culture methods further evidenced the fantastic antibacterial effect and good cytocompatibility of the 3D-AgMOF-CUR. In addition, its high wound healing efficiency was confirmed in vivo, as revealed by improved wound healing efficiency and significantly decreased scar area during the healing process of a wound infection model. This study demonstrated that the layered 3D nanofiber sponge could shed light on the clinical wound healing in the future.

KW - 3D nanofiber sponge

KW - Ag-MOF

KW - Antibacterial

KW - Curcumin

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=85128769196&partnerID=8YFLogxK

U2 - 10.1016/j.cej.2022.136234

DO - 10.1016/j.cej.2022.136234

M3 - Journal article

AN - SCOPUS:85128769196

VL - 443

JO - Chemical Engineering Journal

JF - Chemical Engineering Journal

SN - 1385-8947

M1 - 136234

ER -