Abstract
Objectives
The aim of the present study (part of the NordLOTS) was to examine the long-term outcome of a stepwise treatment for childhood OCD with initial CBT and a comparison between extended treatment with either continued CBT or sertraline for non-responders to initial CBT. Further, the aim was to investigate whether duration of treatment is an important indicator of three-year outcome.
Methods
This long-term follow-up study included 269 participants (48% males) from the NordLOTS sample. All participants were followed over three years (6, 12, 24 and 36 months) after initial CBT, symptom severity was repeatedly assessed with the Children’s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Primary outcome measure was the CY-BOCS, treatment response and remission were defined as CY-BOCS total scores ≤15 and ≤10, respectively. Analyses were conducted according to intent-to-treat principles with linear mixed-effects (LME) model.
Results
At three-year follow-up 73% (n = 196) were free from OCD or in clinical remission, and another 17% (n = 46) responders to treatment. The mean CY-BOCS total score at baseline of 24.7 decreased to 5.0 after three years with a mean decrease of 5.9 from after treatment to three-year follow-up. Duration of treatment did not influence the symptom level at three-year follow-up and no significant difference was found (p = .99) between the different extended treatments.
Conclusion
Findings suggest a long-term durability of gains made by manualized CBT, and if needed, extended treatment with CBT or augmentation with sertraline for pediatric OCD and symptoms decreased even further during the three-year period.
The aim of the present study (part of the NordLOTS) was to examine the long-term outcome of a stepwise treatment for childhood OCD with initial CBT and a comparison between extended treatment with either continued CBT or sertraline for non-responders to initial CBT. Further, the aim was to investigate whether duration of treatment is an important indicator of three-year outcome.
Methods
This long-term follow-up study included 269 participants (48% males) from the NordLOTS sample. All participants were followed over three years (6, 12, 24 and 36 months) after initial CBT, symptom severity was repeatedly assessed with the Children’s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Primary outcome measure was the CY-BOCS, treatment response and remission were defined as CY-BOCS total scores ≤15 and ≤10, respectively. Analyses were conducted according to intent-to-treat principles with linear mixed-effects (LME) model.
Results
At three-year follow-up 73% (n = 196) were free from OCD or in clinical remission, and another 17% (n = 46) responders to treatment. The mean CY-BOCS total score at baseline of 24.7 decreased to 5.0 after three years with a mean decrease of 5.9 from after treatment to three-year follow-up. Duration of treatment did not influence the symptom level at three-year follow-up and no significant difference was found (p = .99) between the different extended treatments.
Conclusion
Findings suggest a long-term durability of gains made by manualized CBT, and if needed, extended treatment with CBT or augmentation with sertraline for pediatric OCD and symptoms decreased even further during the three-year period.
| Original language | English |
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| Publication date | 1 Jul 2023 |
| Publication status | Published - 1 Jul 2023 |
| Event | 20th International Congress of the European Society for Child and Adolescent Psychiatry - Copenhagen, Denmark Duration: 29 Jun 2023 → 1 Jul 2023 Conference number: 20 https://www.escap2023.eu/ |
Conference
| Conference | 20th International Congress of the European Society for Child and Adolescent Psychiatry |
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| Number | 20 |
| Country/Territory | Denmark |
| City | Copenhagen |
| Period | 29/06/2023 → 01/07/2023 |
| Internet address |