Therapeutic targeting of tumor-associated macrophages

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

Abstract

Tumor-associated macrophages are among the most abundant non-cancerous cells in the tumor microenvironment and in many cancers macrophage infiltration into the tumor is associated with poor prognosis. Macrophages contribute to tumor development by promoting angiogenesis and immune suppression, and display remarkable phenotypic heterogeneity in the tumor microenvironment. Therapeutic strategies targeting macrophages that currently are in clinical development are mainly focused on a general depletion of tumor-associated macrophages, either by targeting the CSF-1/CSF-1R axis or by inhibiting macrophage recruitment by blocking CCR2/CCL2 signaling. Despite good pre-clinical response rates the treatment strategies focusing on general macrophage targeting have only shown limited clinical success and new approaches that target specific subsets of tumo-associated macrophages are emerging. This chapter will briefly present the functions and heterogeneity of tumor-associated macrophages and provide an overview of the current state of clinical development for pan-targeting strategies as well as discuss new strategies for targeting specific macrophage subsets for future anti-tumor immunotherapies.

Original languageEnglish
Title of host publicationAdvances in Immunopharmacology
Number of pages27
Place of publicationCambridge
PublisherAcademic Press
Publication date2021
Pages185-211
ISBN (Print)978-0-12-823562-1
DOIs
Publication statusPublished - 2021
SeriesAdvances in Pharmacology
Volume91
ISSN1054-3589

Keywords

  • CCR2
  • CD163
  • CD206
  • CLEVER-1
  • CSFR-1
  • Heterogeneity
  • MARCO
  • TREM2
  • Tumor-associated macrophages

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