Aarhus University Seal / Aarhus Universitets segl

The vasopressor action of angiotensin II (ANG II) in ball pythons (Python regius)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

The vasopressor action of angiotensin II (ANG II) in ball pythons (Python regius). / Hansen, Line Mathilde Brostrup; Wang, Tobias.

In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, Vol. 252, 110839, 02.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hansen, LMB & Wang, T 2021, 'The vasopressor action of angiotensin II (ANG II) in ball pythons (Python regius)', Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, vol. 252, 110839. https://doi.org/10.1016/j.cbpa.2020.110839

APA

Hansen, L. M. B., & Wang, T. (2021). The vasopressor action of angiotensin II (ANG II) in ball pythons (Python regius). Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, 252, [110839]. https://doi.org/10.1016/j.cbpa.2020.110839

CBE

Hansen LMB, Wang T. 2021. The vasopressor action of angiotensin II (ANG II) in ball pythons (Python regius). Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 252:Article 110839. https://doi.org/10.1016/j.cbpa.2020.110839

MLA

Vancouver

Hansen LMB, Wang T. The vasopressor action of angiotensin II (ANG II) in ball pythons (Python regius). Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 2021 Feb;252. 110839. https://doi.org/10.1016/j.cbpa.2020.110839

Author

Hansen, Line Mathilde Brostrup ; Wang, Tobias. / The vasopressor action of angiotensin II (ANG II) in ball pythons (Python regius). In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 2021 ; Vol. 252.

Bibtex

@article{060477fc7513422f870a916fd40f0dcc,
title = "The vasopressor action of angiotensin II (ANG II) in ball pythons (Python regius)",
abstract = "Angiotensin II (ANG II) is part of the renin-angiotensin system (RAS) in vertebrates and exert vasoconstriction in all species studied. The present study examines the vasopressor effect of ANG II in the ball python (Python regius), and examines whether ANG II exert its effect through direct angiotensin receptors or through an activation of α-adrenergic receptors. The studies were conducted in snakes with chronic arterial catheters that had recovered from anesthesia. In addition to demonstrating a clear and pronounced dose-dependent rise in arterial blood pressure upon repeated injections of boluses with ANG II (0.001–1 μg/kg), we demonstrate that the pressor response persisted following α-adrenergic blockade using the α-adrenergic antagonist phentolamine (2.5 mg/kg). Unfortunately, it proved impossible to block the ANG receptors using losartan (1, 3 or even 10 mg/kg). The pressor response to ANG II was associated with a significant rise in heart rate at the higher dosages, pointing to a resetting of the barostatic mechanism for heart rate regulation. The responses were similar in fasting and digesting pythons despite the expected rise in baseline values for blood pressure and heart rate of the digesting snakes.",
keywords = "Adrenergic regulation, ANG II receptors, Blood pressure, Cardiovascular, Digestion, Fasting, Heart rate, Phentolamine, Reptile",
author = "Hansen, {Line Mathilde Brostrup} and Tobias Wang",
note = "Funding Information: T.W. is supported by the Danish Natural Science Research Council and was a recipient of a Skou-fellowship from Aarhus Institute of Advanced Sciences (AIAS) when this study was performed. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
doi = "10.1016/j.cbpa.2020.110839",
language = "English",
volume = "252",
journal = "Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology",
issn = "1095-6433",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The vasopressor action of angiotensin II (ANG II) in ball pythons (Python regius)

AU - Hansen, Line Mathilde Brostrup

AU - Wang, Tobias

N1 - Funding Information: T.W. is supported by the Danish Natural Science Research Council and was a recipient of a Skou-fellowship from Aarhus Institute of Advanced Sciences (AIAS) when this study was performed. Publisher Copyright: © 2020 Elsevier Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021/2

Y1 - 2021/2

N2 - Angiotensin II (ANG II) is part of the renin-angiotensin system (RAS) in vertebrates and exert vasoconstriction in all species studied. The present study examines the vasopressor effect of ANG II in the ball python (Python regius), and examines whether ANG II exert its effect through direct angiotensin receptors or through an activation of α-adrenergic receptors. The studies were conducted in snakes with chronic arterial catheters that had recovered from anesthesia. In addition to demonstrating a clear and pronounced dose-dependent rise in arterial blood pressure upon repeated injections of boluses with ANG II (0.001–1 μg/kg), we demonstrate that the pressor response persisted following α-adrenergic blockade using the α-adrenergic antagonist phentolamine (2.5 mg/kg). Unfortunately, it proved impossible to block the ANG receptors using losartan (1, 3 or even 10 mg/kg). The pressor response to ANG II was associated with a significant rise in heart rate at the higher dosages, pointing to a resetting of the barostatic mechanism for heart rate regulation. The responses were similar in fasting and digesting pythons despite the expected rise in baseline values for blood pressure and heart rate of the digesting snakes.

AB - Angiotensin II (ANG II) is part of the renin-angiotensin system (RAS) in vertebrates and exert vasoconstriction in all species studied. The present study examines the vasopressor effect of ANG II in the ball python (Python regius), and examines whether ANG II exert its effect through direct angiotensin receptors or through an activation of α-adrenergic receptors. The studies were conducted in snakes with chronic arterial catheters that had recovered from anesthesia. In addition to demonstrating a clear and pronounced dose-dependent rise in arterial blood pressure upon repeated injections of boluses with ANG II (0.001–1 μg/kg), we demonstrate that the pressor response persisted following α-adrenergic blockade using the α-adrenergic antagonist phentolamine (2.5 mg/kg). Unfortunately, it proved impossible to block the ANG receptors using losartan (1, 3 or even 10 mg/kg). The pressor response to ANG II was associated with a significant rise in heart rate at the higher dosages, pointing to a resetting of the barostatic mechanism for heart rate regulation. The responses were similar in fasting and digesting pythons despite the expected rise in baseline values for blood pressure and heart rate of the digesting snakes.

KW - Adrenergic regulation

KW - ANG II receptors

KW - Blood pressure

KW - Cardiovascular

KW - Digestion

KW - Fasting

KW - Heart rate

KW - Phentolamine

KW - Reptile

UR - http://www.scopus.com/inward/record.url?scp=85096238023&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2020.110839

DO - 10.1016/j.cbpa.2020.110839

M3 - Journal article

C2 - 33166686

AN - SCOPUS:85096238023

VL - 252

JO - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

JF - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

SN - 1095-6433

M1 - 110839

ER -