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The utility of a point-of-care sural nerve conduction device for detection of diabetic polyneuropathy: A cross-sectional study

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Introduction: Rapid and accessible methods for diagnosing diabetic polyneuropathy (DPN) have been developed, but not validated, in large cohorts of people with diabetes. Methods: The performance of a point-of-care device (POCD) was studied in 168 patients with type 2 diabetes, estimating the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) compared with conventional sural nerve conduction studies (NCS). Results: A POCD amplitude limit of 6 µV increased the sensitivity (96%) and NPV (98%), but decreased the specificity (71%) and PPV (54%) compared with the 4-µV limit, which had values of 78%, 92%, 89%, and 71%, respectively. POCD on both legs showed better performance than on 1 leg. POCD amplitudes and conduction velocities correlated significantly with conventional sural NCS, but POCD values were underestimated compared with NCS. Discussion: The POCD may be used as a suitable screening tool for detection of DPN. Patients with abnormal and borderline results should undergo conventional NCS. Muscle Nerve 59:187–193, 2019.

Original languageEnglish
JournalMuscle & Nerve
Pages (from-to)187-193
Number of pages7
Publication statusPublished - Feb 2019

    Research areas

  • POCD, diabetic polyneuropathy, nerve conduction study, point-of-care nerve conduction device, sural nerve, TRIAL, TESTS, MULTIFACTORIAL THERAPY, PEOPLE, OUTCOMES

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