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The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity

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  • Laurence Lecordier, Université Libre de Bruxelles
  • ,
  • Sophie Uzureau, Université Libre de Bruxelles
  • ,
  • Gilles Vanwalleghem
  • Magali Deleu, University of Liege
  • ,
  • Jean Marc Crowet, University of Liege
  • ,
  • Paul Barry, Trinity College Dublin
  • ,
  • Barry Moran, Trinity College Dublin
  • ,
  • Paul Voorheis, Trinity College Dublin
  • ,
  • Andra Cristina Dumitru, Universite Catholique de Louvain
  • ,
  • Yoshiki Yamaryo-Botté, Universite Grenoble Alpes
  • ,
  • Marc Dieu, Universite de Namur
  • ,
  • Patricia Tebabi, Université Libre de Bruxelles
  • ,
  • Benoit Vanhollebeke, Université Libre de Bruxelles
  • ,
  • Laurence Lins, University of Liege
  • ,
  • Cyrille Y. Botté, Universite Grenoble Alpes
  • ,
  • David Alsteens, Universite Catholique de Louvain
  • ,
  • Yves Dufrêne, Universite Catholique de Louvain
  • ,
  • David Pérez-Morga, Université Libre de Bruxelles
  • ,
  • Derek P. Nolan, Trinity College Dublin
  • ,
  • Etienne Pays, Université Libre de Bruxelles

Immunology; Microbiology Parasite; Cell Biology

Original languageEnglish
Article number101476
JournaliScience
Volume23
Issue9
ISSN2589-0042
DOIs
Publication statusPublished - 25 Sep 2020
Externally publishedYes

Bibliographical note

Funding Information:
We thank V. Flamant for the gift of μMT KO mice, S. Dean for the gift of pPOTv7 plasmid, A. Gauquier for help in the BL approach, and D. Monteyne for SEM analysis. This work was supported by the European Research Council (ERC 669007 -APOLs), the “Action de Recherches Concertées” of the University of Brussels (ULB) (ARC ADV), and the Fonds de la Recherche Scientifique (F.R.S.-FNRS) ( PDR T.0159.13 to D.P.-M and PDR T.1003.14 to L.Lins and M.Deleu). The Center for Microscopy and Molecular Imaging is supported by the European Regional Development Fund and Wallonia. C.Y.B. and Y.Y. are supported by the Atip-Avenir and Fondation FINOVI programs (CNRS-INSERM-Finovi Atip-Avenir Apicolipid projects), and the Laboratoire d’Excellence Parafrap , France (grant number ANR-11-LABX-0024 ). Computational resources have been provided by the Consortium des Equipements de Calcul Intensif (CECI), funded by the FNRS (Grant No. 2.5020.11 ). D.P.N. thanks the Wellcome Trust and Science Foundation Ireland (SFI) for financial support. M.D. and L.L. thank the FRS-FNRS for their positions as Senior Research Associates.

Funding Information:
We thank V. Flamant for the gift of ?MT KO mice, S. Dean for the gift of pPOTv7 plasmid, A. Gauquier for help in the BL approach, and D. Monteyne for SEM analysis. This work was supported by the European Research Council (ERC 669007-APOLs), the ?Action de Recherches Concert?es? of the University of Brussels (ULB) (ARC ADV), and the Fonds de la Recherche Scientifique (F.R.S.-FNRS) (PDR T.0159.13 to D.P.-M and PDR T.1003.14 to L.Lins and M.Deleu). The Center for Microscopy and Molecular Imaging is supported by the European Regional Development Fund and Wallonia. C.Y.B. and Y.Y. are supported by the Atip-Avenir and Fondation FINOVI programs (CNRS-INSERM-Finovi Atip-Avenir Apicolipid projects), and the Laboratoire d'Excellence Parafrap, France (grant number ANR-11-LABX-0024). Computational resources have been provided by the Consortium des Equipements de Calcul Intensif (CECI), funded by the FNRS (Grant No. 2.5020.11). D.P.N. thanks the Wellcome Trust and Science Foundation Ireland (SFI) for financial support. M.D. and L.L. thank the FRS-FNRS for their positions as Senior Research Associates. E.P. D.P.N. and L. Lecordier designed the research; L. Lecordier, S.U. G.V. M.Deleu, J.-M.C. P.B. B.M. A-C.D. Y.Y. M.Dieu, P.T. D.P.-M. and D.P.N. performed the research; B.V. L. Lins, C.Y.B. D.A. Y.D. D.P.-M. and D.P.N. supervised some aspects of the work; E.P. and D.P.N. wrote the paper. The authors declare that they have no competing financial interest.

Publisher Copyright:
© 2020 The Author(s)

    Research areas

  • Cell Biology, Immunology, Microbiology Parasite

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