Department of Economics and Business Economics

The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

DOI

  • Melanie M. Ashton, Deakin University, University of Melbourne
  • ,
  • Olivia M. Dean, Deakin University, University of Melbourne
  • ,
  • Adam J. Walker, Deakin University
  • ,
  • Chiara C. Bortolasci, Deakin University
  • ,
  • Chee H. Ng, University of Melbourne
  • ,
  • Malcolm Hopwood, University of Melbourne
  • ,
  • Brian H. Harvey, North West University
  • ,
  • Marisa Möller, North West University
  • ,
  • John J. McGrath
  • Wolfgang Marx, Deakin University
  • ,
  • Alyna Turner, Deakin University, University of Melbourne
  • ,
  • Seetal Dodd, Deakin University, University of Melbourne
  • ,
  • James G. Scott, Queensland Centre for Mental Health Research, Park Centre for Mental Health, University of Queensland, Royal Brisbane and Women's Hospital
  • ,
  • Jon Paul Khoo, Deakin University, University of Queensland
  • ,
  • Ken Walder, Deakin University
  • ,
  • Jerome Sarris, University of Melbourne, Western Sydney University
  • ,
  • Michael Berk, Deakin University, University of Melbourne, Orygen Youth Health Research Centre

New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.

Original languageEnglish
Article number115
JournalFrontiers in Psychiatry
Volume10
IssueMAR
ISSN1664-0640
DOIs
Publication statusPublished - 2019

    Research areas

  • Bipolar disorder, Inflammation, Mangosteen pericarp, Mitochondria, Oxidative stress, Psychiatry, Schizophrenia

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