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The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations

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  • Interdisciplinary Nanoscience Center
  • Department of Physiology and Biophysics
  • Department of Molecular Biology
  • Department of Molecular Biology
The Na+,K+-ATPase transforms the energy of ATP to the maintenance of steep electrochemical gradients for sodium and potassium across the plasma membrane. This activity is tissue specific, in particular due to variations in the expressions of the alpha subunit isoforms one through four. Several mutations in alpha2 and 3 have been identified that link the specific function of the Na+,K+-ATPase to the pathophysiology of neurological diseases such as rapid-onset dystonia parkinsonism and familial hemiplegic migraine type 2. We show a mapping of the isoform differences and the disease-related mutations on the recently determined crystal structure of the pig renal Na+,K+-ATPase and a structural comparison to Ca2+-ATPase. Furthermore, we present new experimental data that address the role of a stretch of three conserved arginines near the C-terminus of the alpha subunit (Arg1003-Arg1005).
Original languageEnglish
JournalRoyal Society of London. Philosophical Transactions. Biological Sciences
Volume364
Issue1514
Pages (from-to)217-27
ISSN0962-8436
DOIs
Publication statusPublished - 2009

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