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The structure of human interferon lambda and what it has taught us

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Type III interferon (IFN) or IFN-lambda is a novel family of class II cytokines that induces antiviral activities both in vitro and in vivo through its own distinctive receptor complex. The recent crystal structure of human IFN-lambda3 revealed a cytokine with structural similarity to the interleukin-10 family, despite functionally being an IFN. Here, we review the structure of IFN-lambda and its relation to the other members of the class II cytokines. Further, we analyze the structural differences between the tree human isoforms of IFN-lambda and relate this to the observed differences in potency.
Original languageEnglish
JournalJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Volume30
Issue8
Pages (from-to)565-71
Number of pages7
DOIs
Publication statusPublished - 1 Aug 2010

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