The structure and function of the Na,K-ATPase isoforms in health and disease

Michael V. Clausen; Florian Hilbers; Hanne Poulsen

doi:10.3389/fphys.2017.00371

The structure and function of the Na,K-ATPase isoforms in health and disease

Michael V. Clausen, Florian Hilbers, Hanne Poulsen^*

^*Corresponding author for this work

Department of Molecular Biology and Genetics - Plant Molecular Biology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

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Abstract

The sodium and potassium gradients across the plasma membrane are used by animal cells for numerous processes, and the range of demands requires that the responsible ion pump, the Na,K-ATPase, can be fine-tuned to the different cellular needs. Therefore, several isoforms are expressed of each of the three subunits that make a Na,K-ATPase, the alpha, beta and FXYD subunits. This review summarizes the various roles and expression patterns of the Na,K-ATPase subunit isoforms and maps the sequence variations to compare the differences structurally. Mutations in the Na,K-ATPase genes encoding alpha subunit isoforms have severe physiological consequences, causing very distinct, often neurological diseases. The differences in the pathophysiological effects of mutations further underline how the kinetic parameters, regulation and proteomic interactions of the Na,K-ATPase isoforms are optimized for the individual cellular needs.

Original language	English
Article number	371
Journal	Frontiers in Physiology
Volume	8
Issue	JUN
Number of pages	16
ISSN	1664-042X
DOIs	https://doi.org/10.3389/fphys.2017.00371
Publication status	Published - 6 Jun 2017

Keywords

Disease
Expression
Isoforms
K-ATPase
Na
Structure
Subunits

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10.3389/fphys.2017.00371Licence: CC BY

fphys-08-00371Final published version, 2.06 MBLicence: CC BY

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KW - Structure

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The structure and function of the Na,K-ATPase isoforms in health and disease

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Keywords

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