The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections: a large international, multicenter study

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The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections : a large international, multicenter study. / Anderloni, Andrea; Fabbri, Carlo; Nieto, Jose; Uwe, Will; Dollhopf, Markus; Aparicio, José Ramón; Perez-Miranda, Manuel; Tarantino, Ilaria; Arlt, Alexander; Vleggaar, Frank; Vanbiervliet, Geoffrey; Hampe, Jochen; Kahaleh, Michel; Vila, Juan J.; Dayyeh, Barham K.Abu; Storm, Andrew C.; Fugazza, Alessandro; Binda, Cecilia; Charachon, Antoine; Sevilla-Ribota, Sergio; Tyberg, Amy; Robert, Moran; Wani, Sachin; Repici, Alessandro; Sethi, Amrita; Khashab, Mouen A.; Kunda, Rastislav.

In: Surgical Endoscopy, Vol. 35, No. 4, 04.2021, p. 1741-1748.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Anderloni, A, Fabbri, C, Nieto, J, Uwe, W, Dollhopf, M, Aparicio, JR, Perez-Miranda, M, Tarantino, I, Arlt, A, Vleggaar, F, Vanbiervliet, G, Hampe, J, Kahaleh, M, Vila, JJ, Dayyeh, BKA, Storm, AC, Fugazza, A, Binda, C, Charachon, A, Sevilla-Ribota, S, Tyberg, A, Robert, M, Wani, S, Repici, A, Sethi, A, Khashab, MA & Kunda, R 2021, 'The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections: a large international, multicenter study', Surgical Endoscopy, vol. 35, no. 4, pp. 1741-1748. https://doi.org/10.1007/s00464-020-07567-8

APA

Anderloni, A., Fabbri, C., Nieto, J., Uwe, W., Dollhopf, M., Aparicio, J. R., Perez-Miranda, M., Tarantino, I., Arlt, A., Vleggaar, F., Vanbiervliet, G., Hampe, J., Kahaleh, M., Vila, J. J., Dayyeh, B. K. A., Storm, A. C., Fugazza, A., Binda, C., Charachon, A., ... Kunda, R. (2021). The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections: a large international, multicenter study. Surgical Endoscopy, 35(4), 1741-1748. https://doi.org/10.1007/s00464-020-07567-8

CBE

Anderloni A, Fabbri C, Nieto J, Uwe W, Dollhopf M, Aparicio JR, Perez-Miranda M, Tarantino I, Arlt A, Vleggaar F, Vanbiervliet G, Hampe J, Kahaleh M, Vila JJ, Dayyeh BKA, Storm AC, Fugazza A, Binda C, Charachon A, Sevilla-Ribota S, Tyberg A, Robert M, Wani S, Repici A, Sethi A, Khashab MA, Kunda R. 2021. The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections: a large international, multicenter study. Surgical Endoscopy. 35(4):1741-1748. https://doi.org/10.1007/s00464-020-07567-8

MLA

Vancouver

Author

Anderloni, Andrea ; Fabbri, Carlo ; Nieto, Jose ; Uwe, Will ; Dollhopf, Markus ; Aparicio, José Ramón ; Perez-Miranda, Manuel ; Tarantino, Ilaria ; Arlt, Alexander ; Vleggaar, Frank ; Vanbiervliet, Geoffrey ; Hampe, Jochen ; Kahaleh, Michel ; Vila, Juan J. ; Dayyeh, Barham K.Abu ; Storm, Andrew C. ; Fugazza, Alessandro ; Binda, Cecilia ; Charachon, Antoine ; Sevilla-Ribota, Sergio ; Tyberg, Amy ; Robert, Moran ; Wani, Sachin ; Repici, Alessandro ; Sethi, Amrita ; Khashab, Mouen A. ; Kunda, Rastislav. / The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections : a large international, multicenter study. In: Surgical Endoscopy. 2021 ; Vol. 35, No. 4. pp. 1741-1748.

Bibtex

@article{05ca48f493e04a2db1594d4ee9797315,
title = "The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections: a large international, multicenter study",
abstract = "Background: Lumen apposing metal stent (LAMS) allows an easy access to peripancreatic fluid collections (PPFCs) and the possibility of performing direct endoscopic necrosectomy (DEN). The aim of our study was to evaluate the safety and efficacy of a new 20-mm LAMS in the management of PPFCs. This novel stent represents the largest diameter LAMS available on the market to date. Methods: This is an international, multicenter retrospective study involving 20 centers. Consecutive patients who underwent EUS-guided PPFC drainage using a 20-mm LAMS were included. Primary outcomes were technical and clinical success. Secondary outcomes were rate and the severity of adverse events. Results: A total 105 patients underwent PPFC drainage using the new 20-mm LAMS and 106 LAMS were placed. Technical success was 100% (106/106). 7/105 patients died due to causes not related to the stent. Clinical success was achieved in 92/98 patients (93.9%). Significant adverse events occurred in 8/98 patients (8.16%): 4 cases (4.08%) of bleeding, 3 cases (3.06%) of suprainfection, 1 case of gastric outlet obstruction. Conclusions: This multicenter study demonstrated acceptable rates of technical and clinical success using a new 20-mm LAMS for PPFC, including walled-off pancreatic necrosis (WOPN). The results of our study suggest that a new 20-mm LAMS is non-inferior in terms of safety, efficacy, and adverse events as compared to smaller diameter LAMS in the management of PPFCs, including pancreatic psuedocysts (PP) and WOPN. Randomized controlled studies will be needed to determine the ideal size of LAMS need to achieve the greatest clinical benefit with the minimized risk exposure for this high-risk patient population.",
keywords = "EUS-guided drainage, Lumen apposing metal stent, Pancreatic fluid collection, Walled-off pancreatic necrosis",
author = "Andrea Anderloni and Carlo Fabbri and Jose Nieto and Will Uwe and Markus Dollhopf and Aparicio, {Jos{\'e} Ram{\'o}n} and Manuel Perez-Miranda and Ilaria Tarantino and Alexander Arlt and Frank Vleggaar and Geoffrey Vanbiervliet and Jochen Hampe and Michel Kahaleh and Vila, {Juan J.} and Dayyeh, {Barham K.Abu} and Storm, {Andrew C.} and Alessandro Fugazza and Cecilia Binda and Antoine Charachon and Sergio Sevilla-Ribota and Amy Tyberg and Moran Robert and Sachin Wani and Alessandro Repici and Amrita Sethi and Khashab, {Mouen A.} and Rastislav Kunda",
note = "Publisher Copyright: {\textcopyright} 2020, Springer Science+Business Media, LLC, part of Springer Nature. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = apr,
doi = "10.1007/s00464-020-07567-8",
language = "English",
volume = "35",
pages = "1741--1748",
journal = "Surgical Endoscopy",
issn = "0930-2794",
publisher = "Springer New York LLC",
number = "4",

}

RIS

TY - JOUR

T1 - The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections

T2 - a large international, multicenter study

AU - Anderloni, Andrea

AU - Fabbri, Carlo

AU - Nieto, Jose

AU - Uwe, Will

AU - Dollhopf, Markus

AU - Aparicio, José Ramón

AU - Perez-Miranda, Manuel

AU - Tarantino, Ilaria

AU - Arlt, Alexander

AU - Vleggaar, Frank

AU - Vanbiervliet, Geoffrey

AU - Hampe, Jochen

AU - Kahaleh, Michel

AU - Vila, Juan J.

AU - Dayyeh, Barham K.Abu

AU - Storm, Andrew C.

AU - Fugazza, Alessandro

AU - Binda, Cecilia

AU - Charachon, Antoine

AU - Sevilla-Ribota, Sergio

AU - Tyberg, Amy

AU - Robert, Moran

AU - Wani, Sachin

AU - Repici, Alessandro

AU - Sethi, Amrita

AU - Khashab, Mouen A.

AU - Kunda, Rastislav

N1 - Publisher Copyright: © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - Background: Lumen apposing metal stent (LAMS) allows an easy access to peripancreatic fluid collections (PPFCs) and the possibility of performing direct endoscopic necrosectomy (DEN). The aim of our study was to evaluate the safety and efficacy of a new 20-mm LAMS in the management of PPFCs. This novel stent represents the largest diameter LAMS available on the market to date. Methods: This is an international, multicenter retrospective study involving 20 centers. Consecutive patients who underwent EUS-guided PPFC drainage using a 20-mm LAMS were included. Primary outcomes were technical and clinical success. Secondary outcomes were rate and the severity of adverse events. Results: A total 105 patients underwent PPFC drainage using the new 20-mm LAMS and 106 LAMS were placed. Technical success was 100% (106/106). 7/105 patients died due to causes not related to the stent. Clinical success was achieved in 92/98 patients (93.9%). Significant adverse events occurred in 8/98 patients (8.16%): 4 cases (4.08%) of bleeding, 3 cases (3.06%) of suprainfection, 1 case of gastric outlet obstruction. Conclusions: This multicenter study demonstrated acceptable rates of technical and clinical success using a new 20-mm LAMS for PPFC, including walled-off pancreatic necrosis (WOPN). The results of our study suggest that a new 20-mm LAMS is non-inferior in terms of safety, efficacy, and adverse events as compared to smaller diameter LAMS in the management of PPFCs, including pancreatic psuedocysts (PP) and WOPN. Randomized controlled studies will be needed to determine the ideal size of LAMS need to achieve the greatest clinical benefit with the minimized risk exposure for this high-risk patient population.

AB - Background: Lumen apposing metal stent (LAMS) allows an easy access to peripancreatic fluid collections (PPFCs) and the possibility of performing direct endoscopic necrosectomy (DEN). The aim of our study was to evaluate the safety and efficacy of a new 20-mm LAMS in the management of PPFCs. This novel stent represents the largest diameter LAMS available on the market to date. Methods: This is an international, multicenter retrospective study involving 20 centers. Consecutive patients who underwent EUS-guided PPFC drainage using a 20-mm LAMS were included. Primary outcomes were technical and clinical success. Secondary outcomes were rate and the severity of adverse events. Results: A total 105 patients underwent PPFC drainage using the new 20-mm LAMS and 106 LAMS were placed. Technical success was 100% (106/106). 7/105 patients died due to causes not related to the stent. Clinical success was achieved in 92/98 patients (93.9%). Significant adverse events occurred in 8/98 patients (8.16%): 4 cases (4.08%) of bleeding, 3 cases (3.06%) of suprainfection, 1 case of gastric outlet obstruction. Conclusions: This multicenter study demonstrated acceptable rates of technical and clinical success using a new 20-mm LAMS for PPFC, including walled-off pancreatic necrosis (WOPN). The results of our study suggest that a new 20-mm LAMS is non-inferior in terms of safety, efficacy, and adverse events as compared to smaller diameter LAMS in the management of PPFCs, including pancreatic psuedocysts (PP) and WOPN. Randomized controlled studies will be needed to determine the ideal size of LAMS need to achieve the greatest clinical benefit with the minimized risk exposure for this high-risk patient population.

KW - EUS-guided drainage

KW - Lumen apposing metal stent

KW - Pancreatic fluid collection

KW - Walled-off pancreatic necrosis

UR - http://www.scopus.com/inward/record.url?scp=85083796526&partnerID=8YFLogxK

U2 - 10.1007/s00464-020-07567-8

DO - 10.1007/s00464-020-07567-8

M3 - Journal article

C2 - 32323015

AN - SCOPUS:85083796526

VL - 35

SP - 1741

EP - 1748

JO - Surgical Endoscopy

JF - Surgical Endoscopy

SN - 0930-2794

IS - 4

ER -