The role of the striatum and hippocampus in planning: A PET activation study in Parkinson's disease

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  • Alain Dagher, MRC Cognition and Brain Sciences Unit, Cambridge, Montreal Neurological Institute
  • ,
  • Adrian M. Owen, MRC Cognition and Brain Sciences Unit, Cambridge
  • ,
  • Henning Boecker
  • ,
  • David J. Brooks

Previous work has identified the prefrontal cortex (PFC) and striatum as participating in the planning and selection of movements. We compared the brain activation patterns during planning in Parkinson's disease patients and age-matched controls using H215O-PET and the Tower of London (TOL) task. In this study, our mildly affected Parkinson's disease group performed as well as the control group but showed a different pattern of neuronal activation. In the two groups, overlapping areas of the PFC were activated but, whereas the right caudate nucleus was activated in the control group, this was not evident in the Parkinson's disease patients. This suggests that normal normal frontal lobe activation can occur in Parkinson's disease despite abnormal processing within the basal ganglia. Moreover, right hippocampus activity was suppressed in the controls and enhanced in the Parkinson's disease patients. This could represent a shift to the declarative memory system in Parkinson's disease during performance of the TOL task, possibly resulting from insufficient working memory capacity within the frontostriatal system.

Original languageEnglish
JournalBrain
Volume124
Issue5
Pages (from-to)1020-1032
Number of pages13
ISSN0006-8950
Publication statusPublished - 1 May 2001

    Research areas

  • Caudate nucleus, Hippocampus, Parkinson's disease, Positron emission tomography, Tower of London task

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