TY - JOUR
T1 - The role of short luteal phases on cycle regularity during the perimenopausal transition
AU - Visby Madsen, Caroline
AU - Adornetto, Gianluca
AU - Kirkegaard, Kirstine
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2025/3
Y1 - 2025/3
N2 - Objective The aim of the study was to explore the correlation between short luteal phases and cycle irregularity in perimenopausal women. Methods In this feasibility pilot study, daily salivary-progesterone measurements from presumed perimenopausal women have been analyzed using the inne minilab - an at-home system for ovulation and cycle tracking. Data were collected between 2020 to August 2022 from 29 women from Germany and Austria from users over the age of 42 years. Mean age was 44.5 years. The women were divided into two groups based on the presence of short luteal phases. Wilcoxon rank sum test was used to compare the two groups with regard to perimenopausal characteristics: cycle length variability, occurrence, and frequency of short cycles, long cycles, and anovulatory cycles. Results A significant correlation (P value =0.02) was found between short luteal phases and short cycle length under 23 days, with a median of two short cycles in the short luteal phase positive group compared to a median of 0 short cycles in the negative group. However, this correlation did not persist when adjusting for number of observations per participant. No difference was found when comparing other cycle characteristics Conclusions These findings could suggest that it may not be feasible to utilize the occurrence of short luteal phases in the context of expressing the likelihood of cycle irregularity, length, or anovulation. However, because of the small sample size in this study, the null findings could be due to lack of power. Larger studies would be needed to determine how short luteal phases may be correlated to cycle regularity.
AB - Objective The aim of the study was to explore the correlation between short luteal phases and cycle irregularity in perimenopausal women. Methods In this feasibility pilot study, daily salivary-progesterone measurements from presumed perimenopausal women have been analyzed using the inne minilab - an at-home system for ovulation and cycle tracking. Data were collected between 2020 to August 2022 from 29 women from Germany and Austria from users over the age of 42 years. Mean age was 44.5 years. The women were divided into two groups based on the presence of short luteal phases. Wilcoxon rank sum test was used to compare the two groups with regard to perimenopausal characteristics: cycle length variability, occurrence, and frequency of short cycles, long cycles, and anovulatory cycles. Results A significant correlation (P value =0.02) was found between short luteal phases and short cycle length under 23 days, with a median of two short cycles in the short luteal phase positive group compared to a median of 0 short cycles in the negative group. However, this correlation did not persist when adjusting for number of observations per participant. No difference was found when comparing other cycle characteristics Conclusions These findings could suggest that it may not be feasible to utilize the occurrence of short luteal phases in the context of expressing the likelihood of cycle irregularity, length, or anovulation. However, because of the small sample size in this study, the null findings could be due to lack of power. Larger studies would be needed to determine how short luteal phases may be correlated to cycle regularity.
KW - Luteal phase defects
KW - Menopause
KW - Perimenopause
KW - Progesterone
KW - Short luteal phase
UR - http://www.scopus.com/inward/record.url?scp=85214422748&partnerID=8YFLogxK
U2 - 10.1097/GME.0000000000002477
DO - 10.1097/GME.0000000000002477
M3 - Journal article
C2 - 39718569
AN - SCOPUS:85214422748
SN - 1072-3714
VL - 32
SP - 258
EP - 265
JO - Menopause
JF - Menopause
IS - 3
ER -