The role of O-GlcNAcylation in development

Ignacy Czajewski; Daan M F van Aalten

doi:10.1242/dev.201370

The role of O-GlcNAcylation in development

^*Corresponding author for this work

Department of Molecular Biology and Genetics - Cellular Health, Intervention, and Nutrition

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

6 Citations (Scopus)

8 Downloads (Pure)

Abstract

O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.

Original language	English
Article number	dev201370
Journal	Development
Volume	150
Issue	6
ISSN	0950-1991
DOIs	https://doi.org/10.1242/dev.201370
Publication status	Published - Mar 2023

Access to Document

10.1242/dev.201370Licence: CC BY

dev201370Final published version, 597 KBLicence: CC BY

Cite this

@article{f5fd6f89a0924c918a911f39c4d125f7,

title = "The role of O-GlcNAcylation in development",

abstract = "O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.",

author = "Ignacy Czajewski and {van Aalten}, {Daan M F}",

note = "{\textcopyright} 2023. Published by The Company of Biologists Ltd.",

year = "2023",

month = mar,

doi = "10.1242/dev.201370",

language = "English",

volume = "150",

journal = "Development",

issn = "0950-1991",

publisher = "Company of Biologists Ltd",

number = "6",

}

TY - JOUR

T1 - The role of O-GlcNAcylation in development

AU - Czajewski, Ignacy

AU - van Aalten, Daan M F

PY - 2023/3

Y1 - 2023/3

N2 - O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.

AB - O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.

U2 - 10.1242/dev.201370

DO - 10.1242/dev.201370

M3 - Journal article

C2 - 36924340

SN - 0950-1991

VL - 150

JO - Development

JF - Development

IS - 6

M1 - dev201370

ER -

The role of O-GlcNAcylation in development

Abstract

Access to Document

Fingerprint

Cite this