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The role of monoaminergic neurotransmission for metabolic control in the fruit fly drosophila melanogaster

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DOI

  • Yong Li, Christian-Albrechts-Universität zu Kiel, Qingdao University
  • ,
  • Lasse Tiedemann, Christian-Albrechts-Universität zu Kiel
  • ,
  • Jakob Von Frieling, Christian-Albrechts-Universität zu Kiel
  • ,
  • Stella Nolte
  • Samar El-Kholy, Christian-Albrechts-Universität zu Kiel, Tanta University
  • ,
  • Flora Stephano, Christian-Albrechts-Universität zu Kiel, University of Dar Es Salaam
  • ,
  • Christoph Gelhaus, Christian-Albrechts-Universität zu Kiel
  • ,
  • Iris Bruchhaus, Bernhard Nocht Institute for Tropical Medicine
  • ,
  • Christine Fink, Christian-Albrechts-Universität zu Kiel, Airway Research Center North (ARCN)
  • ,
  • Thomas Roeder, Christian-Albrechts-Universität zu Kiel, Airway Research Center North (ARCN)

Hormones control various metabolic traits comprising fat deposition or starvation resistance. Here we show that two invertebrate neurohormones, octopamine (OA) and tyramine (TA) as well as their associated receptors, had a major impact on these metabolic traits. Animals devoid of the monoamine OA develop a severe obesity phenotype. Using flies defective in the expression of receptors for OA and TA, we aimed to decipher the contributions of single receptors for these metabolic phenotypes. Whereas those animals impaired in octβ1r, octβ2r and tar1 share the obesity phenotype of OA-deficient (th-deficient) animals, the octβ1r, octβ2r deficient flies showed reduced insulin release, which is opposed to the situation found in th-deficient animals. On the other hand, OAMB deficient flies were leaner than controls, implying that the regulation of this phenotype is more complex than anticipated. Other phenotypes seen in th-deficient animals, such as the reduced ability to perform complex movements tasks can mainly be attributed to the octβ2r. Tissue-specific RNAi experiments revealed a very complex interorgan communication leading to the different metabolic phenotypes observed in OA or OA and TA-deficient flies.

Original languageEnglish
Article number60
JournalFrontiers in Systems Neuroscience
Volume11
ISSN1662-5137
DOIs
Publication statusPublished - 22 Aug 2017
Externally publishedYes

    Research areas

  • Body fat distribution, Insulin, Insulin release, Octopamine receptor, Tyramine receptor

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