The role of IFN in the development of NAFLD and NASH

Michelle Møhlenberg; Ewa Terczynska-Dyla; Karen Louise Thomsen; Jacob George; Mohammed Eslam; Henning Grønbæk; Rune Hartmann

doi:10.1016/j.cyto.2018.08.013

The role of IFN in the development of NAFLD and NASH

Michelle Møhlenberg, Ewa Terczynska-Dyla, Karen Louise Thomsen, Jacob George, Mohammed Eslam, Henning Grønbæk, Rune Hartmann^*

^*Corresponding author for this work

Department of Clinical Medicine - Hepatology and Gastroenterology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

32 Citations (Scopus)

Abstract

Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in their incidence and prevalence. While NAFLD is largely benign, the chronic liver inflammation in NASH patients may cause progression to liver cirrhosis and hepatocellular carcinoma. There is an urgent need for a better understanding of the factors, which drive the progression from NAFLD to NASH and how to use this information both to improve diagnostic and to develop new treatment strategies. Increasing evidence points to interferons (IFNs) as key players in NAFLD and particular in the progression to NASH. IFNs crucial role in disease development is supported by both genetic evidence and animal studies. In this review, we describe the involvement of both type I and type III IFNs in the development and progression of NAFLD and NASH.

Original language	English
Article number	154519
Journal	Cytokine
Volume	124
Number of pages	6
ISSN	1043-4666
DOIs	https://doi.org/10.1016/j.cyto.2018.08.013
Publication status	Published - 2019

Keywords

Animal models
Humans and human genetics
Interferons (IFN) type I IFN and type III IFN
Non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic steatohepatitis (NASH)

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10.1016/j.cyto.2018.08.013

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title = "The role of IFN in the development of NAFLD and NASH",

abstract = "Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in their incidence and prevalence. While NAFLD is largely benign, the chronic liver inflammation in NASH patients may cause progression to liver cirrhosis and hepatocellular carcinoma. There is an urgent need for a better understanding of the factors, which drive the progression from NAFLD to NASH and how to use this information both to improve diagnostic and to develop new treatment strategies. Increasing evidence points to interferons (IFNs) as key players in NAFLD and particular in the progression to NASH. IFNs crucial role in disease development is supported by both genetic evidence and animal studies. In this review, we describe the involvement of both type I and type III IFNs in the development and progression of NAFLD and NASH.",

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AU - Møhlenberg, Michelle

AU - Terczynska-Dyla, Ewa

AU - Thomsen, Karen Louise

AU - George, Jacob

AU - Eslam, Mohammed

AU - Grønbæk, Henning

AU - Hartmann, Rune

PY - 2019

Y1 - 2019

N2 - Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in their incidence and prevalence. While NAFLD is largely benign, the chronic liver inflammation in NASH patients may cause progression to liver cirrhosis and hepatocellular carcinoma. There is an urgent need for a better understanding of the factors, which drive the progression from NAFLD to NASH and how to use this information both to improve diagnostic and to develop new treatment strategies. Increasing evidence points to interferons (IFNs) as key players in NAFLD and particular in the progression to NASH. IFNs crucial role in disease development is supported by both genetic evidence and animal studies. In this review, we describe the involvement of both type I and type III IFNs in the development and progression of NAFLD and NASH.

AB - Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in their incidence and prevalence. While NAFLD is largely benign, the chronic liver inflammation in NASH patients may cause progression to liver cirrhosis and hepatocellular carcinoma. There is an urgent need for a better understanding of the factors, which drive the progression from NAFLD to NASH and how to use this information both to improve diagnostic and to develop new treatment strategies. Increasing evidence points to interferons (IFNs) as key players in NAFLD and particular in the progression to NASH. IFNs crucial role in disease development is supported by both genetic evidence and animal studies. In this review, we describe the involvement of both type I and type III IFNs in the development and progression of NAFLD and NASH.

KW - Animal models

KW - Humans and human genetics

KW - Interferons (IFN) type I IFN and type III IFN

KW - Non-alcoholic fatty liver disease (NAFLD)

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JO - Cytokine

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ER -

The role of IFN in the development of NAFLD and NASH

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Keywords

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