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The role of H1 antihistamines in contralateral breast cancer: a Danish nationwide cohort study

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  • Annet Bens, Danish Cancer Society
  • ,
  • Christian Dehlendorff, Danish Cancer Society
  • ,
  • Søren Friis, University of Copenhagen, Danish Cancer Society
  • ,
  • Deirdre Cronin-Fenton
  • Maj Britt Jensen, Rigshospitalet
  • ,
  • Bent Ejlertsen, Rigshospitalet
  • ,
  • Timothy L. Lash
  • Niels Kroman, Herlev Hospital
  • ,
  • Lene Mellemkjær, Danish Cancer Society

Background: Preclinical studies have shown both pro- and antineoplastic effects of antihistamines. Here, we evaluated the effect of H1 antihistamines on contralateral breast cancer (CBC) risk, and whether cationic amphiphilic (CAD) antihistamines could increase the sensitivity to chemotherapy. Methods: From the Danish Breast Cancer Group clinical database, we identified all women aged ≥20 years with a first-time diagnosis of breast cancer during 1996–2012. Information on drug use, CBC and potential confounding factors was retrieved from nationwide registries. Using Cox proportional hazard regression models, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for CBC associated with H1-antihistamine use. Results: We identified 52,723 patients with breast cancer with a total of 310,583 person-years of follow-up. Among them, 1444 patients developed a new primary tumour in the contralateral breast. Post-diagnosis use of H1 antihistamines (≥2 prescriptions) was not strongly associated with CBC risk (HR 1.08, 95% CI: 0.90–1.31) compared with non-use (<2 prescriptions). Use of CAD antihistamines among patients receiving chemotherapy was not associated with a decrease in CBC risk. Conclusions: Taken together, our findings do not suggest any association of H1-antihistamine use with CBC development.

Original languageEnglish
JournalBritish Journal of Cancer
Volume122
Issue7
Pages (from-to)1102-1108
Number of pages7
ISSN0007-0920
DOIs
Publication statusPublished - Mar 2020

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