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The RNA Atlas expands the catalog of human non-coding RNAs
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
DOI
- https://doi.org/10.1038/s41587-021-00936-1
Final published version
- Lucia Lorenzi, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Hua Sheng Chiu, Baylor College of Medicine ,
- Francisco Avila Cobos, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Stephen Gross, Illumina ,
- Pieter Jan Volders, Ghent University, Cancer Research Institute Ghent (CRIG), VIB Center for Medical Biotechnology, VIB, Ghent ,
- Robrecht Cannoodt, Ghent University, Cancer Research Institute Ghent (CRIG), Data Intuitive ,
- Justine Nuytens, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Katrien Vanderheyden, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Jasper Anckaert, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Steve Lefever, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Aidan P. Tay, Macquarie University, The Australian e-Health Research Centre, Royal Brisbane and Women's Hospital, Herston, Queensland, AUSTRALIA. ,
- Eric J. de Bony, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Wim Trypsteen, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Fien Gysens, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Marieke Vromman, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Tine Goovaerts, Ghent University ,
- Thomas Birkballe Hansen ,
- Scott Kuersten, Illumina ,
- Nele Nijs, Biogazelle NV ,
- Tom Taghon, Ghent University ,
- Karim Vermaelen, Ghent University ,
- Ken R. Bracke, Ghent University ,
- Yvan Saeys, VIB Center for Medical Biotechnology, VIB, Ghent, Ghent University ,
- Tim De Meyer, Cancer Research Institute Ghent (CRIG), Ghent University ,
- Nandan P. Deshpande, University of New South Wales ,
- Govardhan Anande, University of New South Wales ,
- Ting Wen Chen, National Yang Ming Chiao Tung University ,
- Marc R. Wilkins, University of New South Wales ,
- Ashwin Unnikrishnan, University of New South Wales ,
- Katleen De Preter, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Jørgen Kjems
- Jan Koster, University of Amsterdam ,
- Gary P. Schroth, Illumina ,
- Jo Vandesompele, Ghent University, Cancer Research Institute Ghent (CRIG) ,
- Pavel Sumazin, Baylor College of Medicine ,
- Pieter Mestdagh, Ghent University, Cancer Research Institute Ghent (CRIG)
Existing compendia of non-coding RNA (ncRNA) are incomplete, in part because they are derived almost exclusively from small and polyadenylated RNAs. Here we present a more comprehensive atlas of the human transcriptome, which includes small and polyA RNA as well as total RNA from 300 human tissues and cell lines. We report thousands of previously uncharacterized RNAs, increasing the number of documented ncRNAs by approximately 8%. To infer functional regulation by known and newly characterized ncRNAs, we exploited pre-mRNA abundance estimates from total RNA sequencing, revealing 316 microRNAs and 3,310 long non-coding RNAs with multiple lines of evidence for roles in regulating protein-coding genes and pathways. Our study both refines and expands the current catalog of human ncRNAs and their regulatory interactions. All data, analyses and results are available for download and interrogation in the R2 web portal, serving as a basis for future exploration of RNA biology and function.
| Original language | English |
|---|---|
| Journal | Nature Biotechnology |
| Volume | 39 |
| Issue | 11 |
| Pages (from-to) | 1453-1465 |
| Number of pages | 13 |
| ISSN | 1087-0156 |
| DOIs | |
| Publication status | Published - Nov 2021 |
Bibliographical note
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
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ID: 227300468