The pumps that fuel a sperm's journey

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The sole purpose of a sperm cell is to carry genetic information from a male to a female egg. In order to accomplish this quest, the sperm cell must travel a long distance through a constantly changing environment. The success of this journey depends on membrane proteins that are uniquely expressed in sperm cells. One of these proteins is the α4 isoform of the sodium pump. This pump is optimized to cope with the ionic environment characteristic of the female reproductive tract, and its activity may be tightly coupled with secondary transporters that maintain cytoplasmic pH. Pharmacological inhibition of α4 is sufficient to inhibit sperm motility, and significant differences around the inhibitor-binding site compared with the ubiquitous α1 isoform, make α4 a feasible target in rational drug development.
Original languageEnglish
JournalBiochemical Society. Transactions
Volume39
Issue3
Pages (from-to)741-5
Number of pages5
ISSN0300-5127
DOIs
Publication statusPublished - 2011

    Research areas

  • Animals, Binding Sites, Drug Design, Enzyme Inhibitors, Female, Humans, Hydrogen-Ion Concentration, Ions, Male, Oocytes, Ouabain, Protein Isoforms, Protein Subunits, Sodium-Potassium-Exchanging ATPase, Sperm Motility, Spermatozoa

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