Aarhus University Seal

The power, pitfalls and potential of the nanodisc system for NMR-based studies

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review


  • Aldino Viegas, Heinrich Heine University Düsseldorf
  • ,
  • Thibault Viennet
  • Manuel Etzkorn, Heinrich Heine University Düsseldorf, Jülich Research Centre

The choice of a suitable membrane mimicking environment is of fundamental importance for the characterization of structure and function of membrane proteins. In this respect, usage of the lipid bilayer nanodisc technology provides a unique potential for nuclear magnetic resonance (NMR)-based studies. This review summarizes the recent advances in this field, focusing on (i) the strengths of the system, (ii) the bottlenecks that may be faced, and (iii) promising capabilities that may be explored in future studies.

Original languageEnglish
JournalBiological Chemistry
Pages (from-to)1335-1354
Number of pages20
Publication statusPublished - 1 Dec 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Walter de Gruyter GmbH, Berlin/Boston.

    Research areas

  • membrane proteins, nanodiscs, NMR

See relations at Aarhus University Citationformats

ID: 339525586