The power, pitfalls and potential of the nanodisc system for NMR-based studies

Aldino Viegas; Thibault Viennet; Manuel Etzkorn

doi:10.1515/hsz-2016-0224

The power, pitfalls and potential of the nanodisc system for NMR-based studies

Aldino Viegas, Thibault Viennet, Manuel Etzkorn^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

39 Citations (Scopus)

Abstract

The choice of a suitable membrane mimicking environment is of fundamental importance for the characterization of structure and function of membrane proteins. In this respect, usage of the lipid bilayer nanodisc technology provides a unique potential for nuclear magnetic resonance (NMR)-based studies. This review summarizes the recent advances in this field, focusing on (i) the strengths of the system, (ii) the bottlenecks that may be faced, and (iii) promising capabilities that may be explored in future studies.

Original language	English
Journal	Biological Chemistry
Volume	397
Issue	12
Pages (from-to)	1335-1354
Number of pages	20
ISSN	1431-6730
DOIs	https://doi.org/10.1515/hsz-2016-0224
Publication status	Published - 1 Dec 2016
Externally published	Yes

Keywords

membrane proteins
nanodiscs
NMR

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abstract = "The choice of a suitable membrane mimicking environment is of fundamental importance for the characterization of structure and function of membrane proteins. In this respect, usage of the lipid bilayer nanodisc technology provides a unique potential for nuclear magnetic resonance (NMR)-based studies. This review summarizes the recent advances in this field, focusing on (i) the strengths of the system, (ii) the bottlenecks that may be faced, and (iii) promising capabilities that may be explored in future studies.",

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The power, pitfalls and potential of the nanodisc system for NMR-based studies

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Keywords

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