The OX40 axis is associated with both systemic and local involvement in atopic dermatitis

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Atopic dermatitis (AD) is a chronic, or chronically rel-apsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions are crucial for the genera-tion of TH2 memory cells. Using enzyme-linked immu-noassay (ELISA) and flow cytometry on blood samp-les from patients with AD and healthy volunteers, this study shows that the serum level of soluble (s) OX40 is decreased in patients with AD, and the expression of OX40 by activated skin-homing CD4+ T cells is in-creased. This study further shows, using immunoflu-orescence on skin biopsies, that OX40+ and OX40L+ cells are co-located within the dermis, indicating local activity of OX40/OX40L. Serum levels of sOX40 were associated with atopic diseases and, together, these results support that the OX40 system is important for chronic inflammation in AD skin.

Original languageEnglish
Article numberadv00099
JournalActa Dermato-Venereologica
Number of pages5
Publication statusPublished - Mar 2020

    Research areas

  • Atopic dermatitis, OX40, OX40L

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