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The olfactory bulb coordinates the ventral hippocampus–medial prefrontal cortex circuit during spatial working memory performance

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  • Morteza Salimi, Tarbiat Modarres University
  • ,
  • Farhad Tabasi, Tarbiat Modarres University
  • ,
  • Milad Nazari
  • Sepideh Ghazvineh, Tarbiat Modarres University
  • ,
  • Mohammad Reza Raoufy, Tarbiat Modarres University

Neural oscillations synchronize the activity of brain regions during cognitive functions, such as spatial working memory. Olfactory bulb (OB) oscillations are ubiquitous rhythms that can modulate neocortical and limbic regions. However, the functional connectivity between the OB and areas contributing to spatial working memory, such as the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC), is less understood. Hence, we investigated functional interaction between OB and the vHPC–mPFC circuit during the spatial working memory performance in rats. To this end, we analyzed the simultaneously recorded local field potentials from OB, vHPC, and mPFC when rats explored the Y-maze and compared the brain activities of correct trials vs. wrong trials. We found that coupling between the vHPC and mPFC was augmented during correct trials. The enhanced coherence of OB activity with the vHPC–mPFC circuit at delta (< 4 Hz) and gamma (50–80 Hz) ranges were observed during correct trials. The cross-frequency analysis revealed that the OB delta phase increased the mPFC gamma power within corrected trials, indicating a modulatory role of OB oscillations on mPFC activity during correct trials. Moreover, the correlation between OB oscillations and the vHPC–mPFC circuit was increased at the delta range during correct trials, exhibiting enhanced synchronized activity of these regions during the cognitive task. We demonstrated a functional engagement of OB connectivity with the vHPC–mPFC circuit during spatial working memory task performance.

Original languageEnglish
Article number9
JournalJournal of Physiological Sciences
Volume72
Issue1
ISSN1880-6546
DOIs
Publication statusPublished - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

    Research areas

  • Functional connectivity, Medial prefrontal cortex, Olfactory bulb, Ventral hippocampus, Working memory

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