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The number of glomeruli and pyruvate metabolism is not strongly coupled in the healthy rat kidney

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PURPOSE: The number of glomeruli is different in men and women, as they also present different prevalence and progression of chronic kidney disease. A recent study has demonstrated a potential difference in renal metabolism between sexes, and a potential explanation could be the differences in glomeruli number. This study investigates the potential correlation between glomerular number and pyruvate metabolism in healthy kidneys.

METHODS: This study is an experimental study with rats (N = 12). We used cationized-ferritin MRI to visualize and count glomeruli and hyperpolarized [1-13 C]pyruvate to map the metabolism. Dynamic contrast-enhanced MRI was used to analyze kidney hemodynamics using gadolinium tracer.

RESULTS: Data showed no or subtle correlation between the number of glomeruli and the pyruvate metabolism. Minor differences were observed in the number of glomeruli (female = 24,509 vs. male = 26 350; p = .16), renal plasma flow (female = 606.6 vs. male= 455.7 ml/min/100 g; p = .18), and volume of distribution (female = 87.44 vs. male = 76.61 ml/100 ml; p = .54) between sexes. Mean transit time was significantly prolonged in males compared with females (female = 8.868 s vs. male = 10.63 s; p = .04).

CONCLUSION: No strong statistically correlation between the number of glomeruli and the pyruvate metabolism was found in healthy rat kidneys.

Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume87
Issue2
Pages (from-to)896-903
Number of pages8
ISSN0740-3194
DOIs
Publication statusPublished - Feb 2022

Bibliographical note

© 2021 International Society for Magnetic Resonance in Medicine.

    Research areas

  • MRI, hyperpolarization, renal, sex

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