The nucleotide sequence of the Akv murine leukemia virus genome

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  • M Etzerodt
  • T Mikkelsen, Denmark
  • F S Pedersen, Denmark
  • N O Kjeldgaard, Denmark
  • Poul Jørgensen, Denmark
  • Department of Molecular Biology
  • Department of Molecular Biology
The nucleotide sequence of an infectious molecular clone of the Akv murine leukemia virus has been determined by the dideoxy chain termination method after subcloning in bacteriophage M13 vectors. The sequence predicts an RNA genome of 8371 nucleotides containing three large open reading frames corresponding to the gag, pol, and env genes. Signal sequences for transcription, splicing, and translation have been identified. The positions of 95 major RNase T1 resistant oligonucleotides of the Akv RNA genome have been located.
Original languageEnglish
JournalVirology
Volume134
Issue1
Pages (from-to)196-207
Number of pages11
ISSN0042-6822
Publication statusPublished - 1984

    Research areas

  • AKR murine leukemia virus, Base Sequence, Cloning, Molecular, DNA Restriction Enzymes, Genes, Viral, Leukemia Virus, Murine, Oligoribonucleotides, Poly A, Protein Biosynthesis, RNA, RNA Caps, RNA, Messenger, RNA, Viral, Repetitive Sequences, Nucleic Acid, Ribonuclease T1, Transcription, Genetic, Viral Proteins

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