The nose can be the focus of treatment and prophylactic approaches against COVID-19

Maria Rusan; Thomas Oliver Kamarauskas Ovesen; Kurt Fuursted; Therese Ovesen

The nose can be the focus of treatment and prophylactic approaches against COVID-19

Maria Rusan, Thomas Oliver Kamarauskas Ovesen, Kurt Fuursted, Therese Ovesen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches.

Original language	English
Journal	Ugeskrift for Læger
Volume	183
Issue	37
ISSN	0041-5782
Publication status	Published - 13 Sept 2021

Cite this

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AB - Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches.

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The nose can be the focus of treatment and prophylactic approaches against COVID-19

Abstract

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