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Abstract
Abstract: Objective The purpose of the Nordic Long-
Term OCD Treatment Study (NordLOTS) was to
examine the acute effectiveness of manualized
exposure-based Cognitive Behavioral Therapy (CBT) as
an initial treatment for pediatric Obsessive-Compulsive
Disorder (OCD). Also, to investigate the effectiveness
of sertraline (SRT) versus continued CBT in children
and adolescents who did not respond to the initial course
of CBT. Finally, to describe the 1-year treatment
outcome of the initial CBT responders. Method The
study included 269 participants, age 7-17, diagnosed
with OCD according to DSM-IV. In step I, all received
CBT for 14 weekly sessions. In step II, 54 nonresponders
to CBT were randomized to SRT or
continued CBT for 16 weeks. Treatment response was
in all cases defined as a Children’s Yale-Brown
Obsessive-Compulsive Scale (CY-BOCS) score of =15
at post treatment. The 177 responders to CBT from step
I were assessed with the CY-BOCS at 6- and 12-month
follow-up. Results In step I, 241 participants (89.6%)
completed all 14 weeks of treatment with a treatment
response of 72.6% (95% CI: 66.7%-77.9%) and a mean
symptom reduction on the CY-BOCS of 52.9% (SD =
30.9). In step II, 21 of 28 participants (75 %) completed
continued CBT, and 15 of 22 participants (69.2 %)
completed SRT treatment. The response rate was 50.0 %
in the CBT group and 45.4 % in the SRT group.
Comparison of the CY-BOCS total score did not reveal
a significant difference between the treatment types (p =
0.351). At 1-year follow-up of step I CBT responders
(n=177), a total of 155 (87.6%) were available for
assessment, with 142 (91.6%) still rated as responders.
On average, the CY-BOCS total scores dropped by 1.72
points during the first year after terminating step I CBT
(p = 0.001). Conclusion This study found that CBT can
be applied effectively in community mental health
clinics and that that CBT non-responders are equally
likely to benefit from either continued CBT or treatment
with SSRI. CBT for pediatric OCD is shown to have
durable effects for those who respond to an initial course
of CBT.
Term OCD Treatment Study (NordLOTS) was to
examine the acute effectiveness of manualized
exposure-based Cognitive Behavioral Therapy (CBT) as
an initial treatment for pediatric Obsessive-Compulsive
Disorder (OCD). Also, to investigate the effectiveness
of sertraline (SRT) versus continued CBT in children
and adolescents who did not respond to the initial course
of CBT. Finally, to describe the 1-year treatment
outcome of the initial CBT responders. Method The
study included 269 participants, age 7-17, diagnosed
with OCD according to DSM-IV. In step I, all received
CBT for 14 weekly sessions. In step II, 54 nonresponders
to CBT were randomized to SRT or
continued CBT for 16 weeks. Treatment response was
in all cases defined as a Children’s Yale-Brown
Obsessive-Compulsive Scale (CY-BOCS) score of =15
at post treatment. The 177 responders to CBT from step
I were assessed with the CY-BOCS at 6- and 12-month
follow-up. Results In step I, 241 participants (89.6%)
completed all 14 weeks of treatment with a treatment
response of 72.6% (95% CI: 66.7%-77.9%) and a mean
symptom reduction on the CY-BOCS of 52.9% (SD =
30.9). In step II, 21 of 28 participants (75 %) completed
continued CBT, and 15 of 22 participants (69.2 %)
completed SRT treatment. The response rate was 50.0 %
in the CBT group and 45.4 % in the SRT group.
Comparison of the CY-BOCS total score did not reveal
a significant difference between the treatment types (p =
0.351). At 1-year follow-up of step I CBT responders
(n=177), a total of 155 (87.6%) were available for
assessment, with 142 (91.6%) still rated as responders.
On average, the CY-BOCS total scores dropped by 1.72
points during the first year after terminating step I CBT
(p = 0.001). Conclusion This study found that CBT can
be applied effectively in community mental health
clinics and that that CBT non-responders are equally
likely to benefit from either continued CBT or treatment
with SSRI. CBT for pediatric OCD is shown to have
durable effects for those who respond to an initial course
of CBT.
| Original language | English |
|---|---|
| Publication date | 1 May 2018 |
| Publication status | Published - 1 May 2018 |
| Event | Neuroscience Day 2018: Rewarding Neuroscience - Aarhus University, Aarhus, Denmark Duration: 1 May 2018 → 1 May 2018 http://neurocampus.au.dk/neuroscience-day/neuroscience-day-2018/ |
Conference
| Conference | Neuroscience Day 2018 |
|---|---|
| Location | Aarhus University |
| Country/Territory | Denmark |
| City | Aarhus |
| Period | 01/05/2018 → 01/05/2018 |
| Internet address |
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Nordic Long-Term OCD Treatment Study (NordLOTS)
Højgaard, D. R. M. A. (PI) & Thomsen, P. H. (PI)
01/01/2012 → …
Project: Research