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The mannan-binding lectin pathway of complement activation: biology and disease association.

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The mannan-binding lectin pathway of complement activation: biology and disease association. / Petersen, Steen Vang; Thiel, S; Jensenius, J C.

In: Molecular Immunology, Vol. 38, No. 2-3, 2001, p. 133-49.

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@article{7573fc10fbda11dcb919000ea68e967b,
title = "The mannan-binding lectin pathway of complement activation: biology and disease association.",
abstract = "Mannan-binding lectin (MBL) is a plasma protein found in association with several serine proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures arranged in a particular geometry, such as those found on the surface of micro-organisms. When bound to e.g. bacteria the MBL complex will initiate the activation of the complement cascade. Mounting evidence supports the importance of the MBL pathway of complement activation in innate immunity. In this review, we focus on the structure and function of the proteins within the MBL pathway and address the properties of the pathway as an initiator of the host response against potential pathogenic micro-organisms. Udgivelsesdato: 2001-Aug",
keywords = "Amino Acid Sequence, Autoimmune Diseases, Blood Proteins, Carrier Proteins, Collectins, Communicable Diseases, Complement Activation, Immunity, Natural, Lectins, Mannans, Molecular Sequence Data",
author = "Petersen, {Steen Vang} and S Thiel and Jensenius, {J C}",
year = "2001",
language = "English",
volume = "38",
pages = "133--49",
journal = "Molecular Immunology",
issn = "0161-5890",
publisher = "Pergamon Press",
number = "2-3",

}

RIS

TY - JOUR

T1 - The mannan-binding lectin pathway of complement activation: biology and disease association.

AU - Petersen, Steen Vang

AU - Thiel, S

AU - Jensenius, J C

PY - 2001

Y1 - 2001

N2 - Mannan-binding lectin (MBL) is a plasma protein found in association with several serine proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures arranged in a particular geometry, such as those found on the surface of micro-organisms. When bound to e.g. bacteria the MBL complex will initiate the activation of the complement cascade. Mounting evidence supports the importance of the MBL pathway of complement activation in innate immunity. In this review, we focus on the structure and function of the proteins within the MBL pathway and address the properties of the pathway as an initiator of the host response against potential pathogenic micro-organisms. Udgivelsesdato: 2001-Aug

AB - Mannan-binding lectin (MBL) is a plasma protein found in association with several serine proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures arranged in a particular geometry, such as those found on the surface of micro-organisms. When bound to e.g. bacteria the MBL complex will initiate the activation of the complement cascade. Mounting evidence supports the importance of the MBL pathway of complement activation in innate immunity. In this review, we focus on the structure and function of the proteins within the MBL pathway and address the properties of the pathway as an initiator of the host response against potential pathogenic micro-organisms. Udgivelsesdato: 2001-Aug

KW - Amino Acid Sequence

KW - Autoimmune Diseases

KW - Blood Proteins

KW - Carrier Proteins

KW - Collectins

KW - Communicable Diseases

KW - Complement Activation

KW - Immunity, Natural

KW - Lectins

KW - Mannans

KW - Molecular Sequence Data

M3 - Journal article

C2 - 11532276

VL - 38

SP - 133

EP - 149

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

IS - 2-3

ER -