The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Christine A. Wells, Griffith Univ, Griffith University, Natl Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies
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  • Judith A. Salvage-Jones, Griffith Univ, Griffith University, Natl Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies
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  • Xin Li, Univ Queensland, University of Queensland, Sch Dent
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  • Kelly Hitchens, Griffith Univ, Griffith University, Natl Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies
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  • Suzanne Butcher, Griffith Univ, Griffith University, Natl Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies
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  • Rachael Z. Murray, Univ Queensland, University of Queensland, Inst Mol Biosci
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  • Anthony G. Beckhouse, Griffith Univ, Griffith University, Natl Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies
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  • Yu-Lan-Sandra Lo, Griffith Univ, Griffith University, Natl Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies
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  • Silvia Manzanero, Griffith Univ, Griffith University, Natl Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies
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  • Christian Cobbold, Griffith Univ, Griffith University, Natl Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies
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  • Kate Schroder, Univ Queensland, University of Queensland, Inst Mol Biosci
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  • Bo Ma, Scripps Res Inst, Scripps Research Institute, Dept Mol Biol, Consortium Funct Glyc
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  • Sally Orr, Scripps Res Inst, Scripps Research Institute, Dept Mol Biol, Consortium Funct Glyc
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  • Lauren Stewart, Scripps Res Inst, Scripps Research Institute, Dept Mol Biol, Consortium Funct Glyc
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  • Daniel Lebus, Scripps Res Inst, Scripps Research Institute, Dept Mol Biol, Consortium Funct Glyc
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  • Peter Sobieszczuk, Scripps Res Inst, Scripps Research Institute, Dept Mol Biol, Consortium Funct Glyc
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  • David A. Hume, Univ Queensland, University of Queensland, Inst Mol Biosci
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  • Jennifer Stow
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  • Helen Blanchard, Griffith Univ, Griffith University, Inst Glyc
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  • Robert B. Ashman, Univ Queensland, University of Queensland, Sch Dent

The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-alpha by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nouredundant role in the induction of inflammatory signaling in response to C. albicans infection.

Original languageEnglish
JournalJournal of Immunology
Volume180
Issue11
Pages (from-to)7404-7413
Number of pages10
ISSN0022-1767
Publication statusPublished - 1 Jun 2008

    Research areas

  • TOLL-LIKE RECEPTORS, INCREASES SUSCEPTIBILITY, MURINE MACROPHAGES, GENE-EXPRESSION, RECOGNITION, INFECTION, DECTIN-1, REVEALS, IDENTIFICATION, GALECTIN-3

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ID: 90217606