The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans

Christine A. Wells, Judith A. Salvage-Jones, Xin Li, Kelly Hitchens, Suzanne Butcher, Rachael Z. Murray, Anthony G. Beckhouse, Yu-Lan-Sandra Lo, Silvia Manzanero, Christian Cobbold, Kate Schroder, Bo Ma, Sally Orr, Lauren Stewart, Daniel Lebus, Peter Sobieszczuk, David A. Hume, Jennifer Stow, Helen Blanchard, Robert B. Ashman*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-alpha by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nouredundant role in the induction of inflammatory signaling in response to C. albicans infection.

Original languageEnglish
JournalJournal of Immunology
Volume180
Issue11
Pages (from-to)7404-7413
Number of pages10
ISSN0022-1767
Publication statusPublished - 1 Jun 2008

Keywords

  • TOLL-LIKE RECEPTORS
  • INCREASES SUSCEPTIBILITY
  • MURINE MACROPHAGES
  • GENE-EXPRESSION
  • RECOGNITION
  • INFECTION
  • DECTIN-1
  • REVEALS
  • IDENTIFICATION
  • GALECTIN-3

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