The laparoscopic implantation of neuroprosthesis procedure increases leg lean mass in individuals with paraplegia due to traumatic spinal cord injury  

TY - JOUR

T1 - The laparoscopic implantation of neuroprosthesis procedure increases leg lean mass in individuals with paraplegia due to traumatic spinal cord injury  

AU - Løve, Uffe Schou

AU - Kasch, Helge

AU - Severinsen, Kåre

AU - Abrahamsen, Jan

AU - Høyer, Christian

AU - Forman, Axel

AU - Thomsen, Henrik Holm

PY - 2023/12

Y1 - 2023/12

N2 - OBJECTIVES: We hypothesized that the laparoscopic implantation of neuroprosthesis (LION) procedure would significantly alter the body composition of patients with chronic traumatic spinal cord injury (SCI). The objectives were to determine the effect of the LION procedure on lean mass (LM), fatty mass (FM), and bone mineral content (BMC) in patients with SCI.MATERIALS AND METHODS: Five consecutive patients underwent dual-energy x-ray absorptiometry scans before the LION procedure and at the one-year postoperative follow-up to determine changes in LM, FM, and BMC. Student paired t-test was used to determine significance.RESULTS: The patients gained 2506 ± 565 g of LM in the legs (p < 0.001), which was an 18% total increase in leg LM. Total body LM was significantly increased by 3523 ± 1048 g (p < 0.003). FM was unaffected, whereas total BMC showed a small but significant increase of 99 ± 42 g (p = 0.009).CONCLUSIONS: The LION procedure and subsequent neurostimulation procedures resulted in substantial increases in leg LM in patients with chronic traumatic SCI and paraplegia. A possible incremental effect on total BMC also was observed. Further studies are needed to confirm and expand these promising results.

AB - OBJECTIVES: We hypothesized that the laparoscopic implantation of neuroprosthesis (LION) procedure would significantly alter the body composition of patients with chronic traumatic spinal cord injury (SCI). The objectives were to determine the effect of the LION procedure on lean mass (LM), fatty mass (FM), and bone mineral content (BMC) in patients with SCI.MATERIALS AND METHODS: Five consecutive patients underwent dual-energy x-ray absorptiometry scans before the LION procedure and at the one-year postoperative follow-up to determine changes in LM, FM, and BMC. Student paired t-test was used to determine significance.RESULTS: The patients gained 2506 ± 565 g of LM in the legs (p < 0.001), which was an 18% total increase in leg LM. Total body LM was significantly increased by 3523 ± 1048 g (p < 0.003). FM was unaffected, whereas total BMC showed a small but significant increase of 99 ± 42 g (p = 0.009).CONCLUSIONS: The LION procedure and subsequent neurostimulation procedures resulted in substantial increases in leg LM in patients with chronic traumatic SCI and paraplegia. A possible incremental effect on total BMC also was observed. Further studies are needed to confirm and expand these promising results.

KW - Bone mineral content

KW - functional electrical stimulation

KW - lean mass

KW - LION procedure

KW - spinal cord injury

UR - http://www.scopus.com/inward/record.url?scp=85131808695&partnerID=8YFLogxK

U2 - 10.1016/j.neurom.2022.04.044

DO - 10.1016/j.neurom.2022.04.044

M3 - Journal article

C2 - 35690509

SN - 1094-7159

VL - 26

SP - 1802

EP - 1807

JO - Neuromodulation: Technology at the Neural Interface

JF - Neuromodulation: Technology at the Neural Interface

IS - 8

ER -