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The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders

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The iPSYCH2012 case-cohort sample : new directions for unravelling genetic and environmental architectures of severe mental disorders. / Pedersen, C B; Bybjerg-Grauholm, J; Pedersen, M G et al.

In: Molecular Psychiatry, Vol. 23, No. 1, 2018, p. 6–14.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Pedersen, CB, Bybjerg-Grauholm, J, Pedersen, MG, Grove, J, Agerbo, E, Bækvad-Hansen, M, Poulsen, JB, Hansen, CS, McGrath, JJ, Als, TD, Goldstein, JI, Neale, BM, Daly, MJ, Hougaard, DM, Mors, O, Nordentoft, M, Børglum, AD, Werge, T & Mortensen, PB 2018, 'The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders', Molecular Psychiatry, vol. 23, no. 1, pp. 6–14. https://doi.org/10.1038/mp.2017.196

APA

Pedersen, C. B., Bybjerg-Grauholm, J., Pedersen, M. G., Grove, J., Agerbo, E., Bækvad-Hansen, M., Poulsen, J. B., Hansen, C. S., McGrath, J. J., Als, T. D., Goldstein, J. I., Neale, B. M., Daly, M. J., Hougaard, D. M., Mors, O., Nordentoft, M., Børglum, A. D., Werge, T., & Mortensen, P. B. (2018). The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders. Molecular Psychiatry, 23(1), 6–14. https://doi.org/10.1038/mp.2017.196

CBE

Pedersen CB, Bybjerg-Grauholm J, Pedersen MG, Grove J, Agerbo E, Bækvad-Hansen M, Poulsen JB, Hansen CS, McGrath JJ, Als TD, et al. 2018. The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders. Molecular Psychiatry. 23(1):6–14. https://doi.org/10.1038/mp.2017.196

MLA

Pedersen, C B et al. "The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders". Molecular Psychiatry. 2018, 23(1). 6–14. https://doi.org/10.1038/mp.2017.196

Vancouver

Pedersen CB, Bybjerg-Grauholm J, Pedersen MG, Grove J, Agerbo E, Bækvad-Hansen M et al. The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders. Molecular Psychiatry. 2018;23(1):6–14. Epub 2017 Sep 19. doi: 10.1038/mp.2017.196

Author

Pedersen, C B ; Bybjerg-Grauholm, J ; Pedersen, M G et al. / The iPSYCH2012 case-cohort sample : new directions for unravelling genetic and environmental architectures of severe mental disorders. In: Molecular Psychiatry. 2018 ; Vol. 23, No. 1. pp. 6–14.

Bibtex

@article{b3aee47f3d104de9acc48540a9fab0c6,
title = "The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders",
abstract = "The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder. Controls were randomly sampled individuals (N=30 000). Within the sample of 86 189 individuals, a total of 57 377 individuals had at least one major mental disorder. DNA was extracted from the neonatal dried blood spot samples obtained from the Danish Neonatal Screening Biobank and genotyped using the Illumina PsychChip. Genotyping was successful for 90% of the sample. The assessments of exome sequencing, methylation profiling, metabolome profiling, vitamin-D, inflammatory and neurotrophic factors are in progress. For each individual, the iPSYCH2012 sample also includes longitudinal information on health, prescribed medicine, social and socioeconomic information, and analogous information among relatives. To the best of our knowledge, the iPSYCH2012 sample is the largest and most comprehensive data source for the combined study of genetic and environmental aetiologies of severe mental disorders.Molecular Psychiatry advance online publication, 19 September 2017; doi:10.1038/mp.2017.196.",
keywords = "Adolescent, Adult, Age Factors, Child, Cohort Studies, Denmark, Environment, Female, Genetic Predisposition to Disease/genetics, Genotype, Humans, Male, Mental Disorders/classification, Psychiatric Status Rating Scales, Severity of Illness Index, Young Adult",
author = "Pedersen, {C B} and J Bybjerg-Grauholm and Pedersen, {M G} and Jakob Grove and E Agerbo and M B{\ae}kvad-Hansen and Poulsen, {J B} and Hansen, {C S} and McGrath, {J J} and Als, {T D} and Goldstein, {J I} and Neale, {B M} and Daly, {M J} and Hougaard, {D M} and O Mors and M Nordentoft and B{\o}rglum, {A D} and T Werge and Mortensen, {P B}",
year = "2018",
doi = "10.1038/mp.2017.196",
language = "English",
volume = "23",
pages = "6–14",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - The iPSYCH2012 case-cohort sample

T2 - new directions for unravelling genetic and environmental architectures of severe mental disorders

AU - Pedersen, C B

AU - Bybjerg-Grauholm, J

AU - Pedersen, M G

AU - Grove, Jakob

AU - Agerbo, E

AU - Bækvad-Hansen, M

AU - Poulsen, J B

AU - Hansen, C S

AU - McGrath, J J

AU - Als, T D

AU - Goldstein, J I

AU - Neale, B M

AU - Daly, M J

AU - Hougaard, D M

AU - Mors, O

AU - Nordentoft, M

AU - Børglum, A D

AU - Werge, T

AU - Mortensen, P B

PY - 2018

Y1 - 2018

N2 - The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder. Controls were randomly sampled individuals (N=30 000). Within the sample of 86 189 individuals, a total of 57 377 individuals had at least one major mental disorder. DNA was extracted from the neonatal dried blood spot samples obtained from the Danish Neonatal Screening Biobank and genotyped using the Illumina PsychChip. Genotyping was successful for 90% of the sample. The assessments of exome sequencing, methylation profiling, metabolome profiling, vitamin-D, inflammatory and neurotrophic factors are in progress. For each individual, the iPSYCH2012 sample also includes longitudinal information on health, prescribed medicine, social and socioeconomic information, and analogous information among relatives. To the best of our knowledge, the iPSYCH2012 sample is the largest and most comprehensive data source for the combined study of genetic and environmental aetiologies of severe mental disorders.Molecular Psychiatry advance online publication, 19 September 2017; doi:10.1038/mp.2017.196.

AB - The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder. Controls were randomly sampled individuals (N=30 000). Within the sample of 86 189 individuals, a total of 57 377 individuals had at least one major mental disorder. DNA was extracted from the neonatal dried blood spot samples obtained from the Danish Neonatal Screening Biobank and genotyped using the Illumina PsychChip. Genotyping was successful for 90% of the sample. The assessments of exome sequencing, methylation profiling, metabolome profiling, vitamin-D, inflammatory and neurotrophic factors are in progress. For each individual, the iPSYCH2012 sample also includes longitudinal information on health, prescribed medicine, social and socioeconomic information, and analogous information among relatives. To the best of our knowledge, the iPSYCH2012 sample is the largest and most comprehensive data source for the combined study of genetic and environmental aetiologies of severe mental disorders.Molecular Psychiatry advance online publication, 19 September 2017; doi:10.1038/mp.2017.196.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Child

KW - Cohort Studies

KW - Denmark

KW - Environment

KW - Female

KW - Genetic Predisposition to Disease/genetics

KW - Genotype

KW - Humans

KW - Male

KW - Mental Disorders/classification

KW - Psychiatric Status Rating Scales

KW - Severity of Illness Index

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85040051369&partnerID=8YFLogxK

U2 - 10.1038/mp.2017.196

DO - 10.1038/mp.2017.196

M3 - Journal article

C2 - 28924187

VL - 23

SP - 6

EP - 14

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 1

ER -