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The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders

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DOI

  • C B Pedersen
  • J Bybjerg-Grauholm, iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Statens Serum Institut, Denmark
  • M G Pedersen
  • Jakob Grove
  • E Agerbo
  • M Bækvad-Hansen, Statens Serum Institut, Denmark
  • J B Poulsen, iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Statens Serum Institut, Denmark
  • C S Hansen, iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Statens Serum Institut, Denmark
  • J J McGrath
  • T D Als
  • J I Goldstein, Massachusetts General Hospital and Harvard Medical School, Broad Institute of Harvard and MIT, United States
  • B M Neale, 1] Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA [2] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • ,
  • M J Daly, Massachusetts General Hospital and Harvard Medical School, Broad Institute of Harvard and MIT, United States
  • D M Hougaard, iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Statens Serum Institut, Denmark
  • O Mors
  • M Nordentoft, iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen University Hospital, Denmark
  • A D Børglum
  • T Werge, iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen University Hospital, Denmark
  • P B Mortensen

The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder. Controls were randomly sampled individuals (N=30 000). Within the sample of 86 189 individuals, a total of 57 377 individuals had at least one major mental disorder. DNA was extracted from the neonatal dried blood spot samples obtained from the Danish Neonatal Screening Biobank and genotyped using the Illumina PsychChip. Genotyping was successful for 90% of the sample. The assessments of exome sequencing, methylation profiling, metabolome profiling, vitamin-D, inflammatory and neurotrophic factors are in progress. For each individual, the iPSYCH2012 sample also includes longitudinal information on health, prescribed medicine, social and socioeconomic information, and analogous information among relatives. To the best of our knowledge, the iPSYCH2012 sample is the largest and most comprehensive data source for the combined study of genetic and environmental aetiologies of severe mental disorders.Molecular Psychiatry advance online publication, 19 September 2017; doi:10.1038/mp.2017.196.

Original languageEnglish
JournalMolecular Psychiatry
Volume23
Issue1
Pages (from-to)6–14
Number of pages9
ISSN1359-4184
DOIs
Publication statusPublished - 2018

    Research areas

  • Adolescent, Adult, Age Factors, Child, Cohort Studies, Denmark, Environment, Female, Genetic Predisposition to Disease/genetics, Genotype, Humans, Male, Mental Disorders/classification, Psychiatric Status Rating Scales, Severity of Illness Index, Young Adult

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