The Interaction between Nidovirales and Autophagy Components

Yingying Cong; Pauline Verlhac; Fulvio Reggiori

doi:10.3390/v9070182

The Interaction between Nidovirales and Autophagy Components

Yingying Cong, Pauline Verlhac, Fulvio Reggiori

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

32 Citations (Scopus)

Abstract

Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numerous pathogens, including viruses, usurp autophagy in order to promote their propagation. Nidovirales are an order of enveloped viruses with large single-stranded positive RNA genomes. Four virus families (Arterividae, Coronaviridae, Mesoniviridae, and Roniviridae) are part of this order, which comprises several human and animal pathogens of medical and veterinary importance. In host cells, Nidovirales induce membrane rearrangements including autophagosome formation. The relevance and putative mechanism of autophagy usurpation, however, remain largely elusive. Here, we review the current knowledge about the possible interplay between Nidovirales and autophagy.

Original language	English
Journal	Viruses
Volume	9
Issue	7
ISSN	1999-4915
DOIs	https://doi.org/10.3390/v9070182
Publication status	Published - 11 Jul 2017

Keywords

Animals
Autophagy
Host-Pathogen Interactions
Humans
Nidovirales/physiology
Virus Replication

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title = "The Interaction between Nidovirales and Autophagy Components",

abstract = "Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numerous pathogens, including viruses, usurp autophagy in order to promote their propagation. Nidovirales are an order of enveloped viruses with large single-stranded positive RNA genomes. Four virus families (Arterividae, Coronaviridae, Mesoniviridae, and Roniviridae) are part of this order, which comprises several human and animal pathogens of medical and veterinary importance. In host cells, Nidovirales induce membrane rearrangements including autophagosome formation. The relevance and putative mechanism of autophagy usurpation, however, remain largely elusive. Here, we review the current knowledge about the possible interplay between Nidovirales and autophagy.",

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AU - Reggiori, Fulvio

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AB - Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numerous pathogens, including viruses, usurp autophagy in order to promote their propagation. Nidovirales are an order of enveloped viruses with large single-stranded positive RNA genomes. Four virus families (Arterividae, Coronaviridae, Mesoniviridae, and Roniviridae) are part of this order, which comprises several human and animal pathogens of medical and veterinary importance. In host cells, Nidovirales induce membrane rearrangements including autophagosome formation. The relevance and putative mechanism of autophagy usurpation, however, remain largely elusive. Here, we review the current knowledge about the possible interplay between Nidovirales and autophagy.

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KW - Host-Pathogen Interactions

KW - Humans

KW - Nidovirales/physiology

KW - Virus Replication

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SN - 1999-4915

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JO - Viruses

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The Interaction between Nidovirales and Autophagy Components

Abstract

Keywords

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