The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • B Brock, Denmark
  • S Gregersen, Denmark
  • K Kristensen, Denmark
  • J L Thomsen, Denmark
  • Karen Kaas Buschard, Department of Energy Engineering, Denmark
  • Hans Kofod, Afd. for Celle og Metabolismeforskning, Denmark
  • K Hermansen
  • Kurt Kristensen
The circulating concentrations of endothelin-1 (ET-1), a peptide derived from endothelium, are increased in hypertension and diabetes. Endothelin-1 has recently been shown to be an insulinotropic agent. The mechanism of action of endothelin-1 on the endocrine pancreas has not yet been clarified.
Original languageEnglish
JournalDiabetologia
Volume42
Issue11
Pages (from-to)1302-7
Number of pages6
ISSN0012-186X
DOIs
Publication statusPublished - 1999

    Research areas

  • Animals, Cell Line, Endothelin-1, Glucagon, Insulin, Islets of Langerhans, Male, RNA, Messenger, Rats, Rats, Inbred Lew, Receptor, Endothelin A, Receptors, Endothelin, Reverse Transcriptase Polymerase Chain Reaction

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