The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells

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DOI

https://doi.org/10.1007/s001250051442

B Brock, Denmark
S Gregersen, Denmark
K Kristensen, Denmark
J L Thomsen, Denmark
Karen Kaas Buschard, Department of Energy Engineering, Denmark
Hans Kofod, Afd. for Celle og Metabolismeforskning, Denmark
K Hermansen
Kurt Kristensen

The circulating concentrations of endothelin-1 (ET-1), a peptide derived from endothelium, are increased in hypertension and diabetes. Endothelin-1 has recently been shown to be an insulinotropic agent. The mechanism of action of endothelin-1 on the endocrine pancreas has not yet been clarified.

Original language	English
Journal	Diabetologia
Volume	42
Issue	11
Pages (from-to)	1302-7
Number of pages	6
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s001250051442
Publication status	Published - 1999

Research areas

Animals, Cell Line, Endothelin-1, Glucagon, Insulin, Islets of Langerhans, Male, RNA, Messenger, Rats, Rats, Inbred Lew, Receptor, Endothelin A, Receptors, Endothelin, Reverse Transcriptase Polymerase Chain Reaction

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