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The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
B Brock, Denmark S Gregersen, Denmark K Kristensen, Denmark J L Thomsen, Denmark Karen Kaas Buschard, Department of Energy Engineering, Denmark Hans Kofod, Afd. for Celle og Metabolismeforskning, Denmark K Hermansen Kurt Kristensen The circulating concentrations of endothelin-1 (ET-1), a peptide derived from endothelium, are increased in hypertension and diabetes. Endothelin-1 has recently been shown to be an insulinotropic agent. The mechanism of action of endothelin-1 on the endocrine pancreas has not yet been clarified.
Original language English Journal Diabetologia Volume 42 Issue 11 Pages (from-to) 1302-7 Number of pages 6 ISSN 0012-186X DOIs Publication status Published - 1999
Animals, Cell Line, Endothelin-1, Glucagon, Insulin, Islets of Langerhans, Male, RNA, Messenger, Rats, Rats, Inbred Lew, Receptor, Endothelin A, Receptors, Endothelin, Reverse Transcriptase Polymerase Chain Reaction
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