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The Influence of IgE on Cultured Human Mast Cells

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  • Pernille Munk Frandsen, Denmark
  • Inge Jacoba Maria Kortekaas Krohn, Denmark
  • Hans Jürgen Hoffmann
  • Peter Oluf Schiøtz, Denmark
The mast cell plays a pivotal role in the human immune response. Crosslinking of 2 IgE molecules bound to the high affinity IgE receptor (FcεRI) on the surface of the mast cell results in mast cell degranulation and the release of several proinflammatory mediators. Patients with type-I allergy have increased levels of IgE in the blood compared to healthy individuals.
Original languageEnglish
JournalAllergy, Asthma & Immunology Research
Volume5
Issue6
Pages (from-to)409-14
Number of pages6
ISSN2092-7355
DOIs
Publication statusPublished - Nov 2013

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