The importance of determining necrotic fraction when studying the effect of tumour volume on tissue oxygenation

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Abstract

The relationship between tumour tissue oxygenation and necrosis at different tumour sizes was investigated in a C3H mammary carcinoma implanted in the feet of female CDF1 mice. Experiments were performed using tumours that ranged in size from 80 to 800 mm3. Necrosis was estimated histologically. Tumour tissue oxygenation (pO2) was estimated with an Eppendorf electrode. Our results showed that as tumour volume increased there was a corresponding increase in necrotic fraction ranging from 1% in small tumours up to 51% in large tumours. The percentage of pO2 values
Original languageEnglish
JournalActa Oncologica
Volume34
Issue3
Pages (from-to)297-300
Number of pages4
ISSN0284-186X
Publication statusPublished - 1995

Keywords

  • Animals
  • Female
  • Mammary Neoplasms, Experimental
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred Strains
  • Necrosis
  • Oxygen
  • Oxygen Consumption
  • Partial Pressure
  • Regression Analysis

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