The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa M Dinh; Ole B Pedersen; Mikkel S Petersen; Erik Sørensen; Cecilie J Sørensen; Kathrine A Kaspersen; Margit H Larsen; Bjarne Møller; Henrik Hjalgrim; Henrik Ullum; Christian Erikstrup

doi:10.1016/j.atherosclerosis.2015.07.031

The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa M Dinh, Ole B Pedersen, Mikkel S Petersen, Erik Sørensen, Cecilie J Sørensen, Kathrine A Kaspersen, Margit H Larsen, Bjarne Møller, Henrik Hjalgrim, Henrik Ullum, Christian Erikstrup

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.

METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.

RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.

CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

Original language	English
Journal	Atherosclerosis
Volume	242
Issue	1
Pages (from-to)	222-5
Number of pages	4
ISSN	0021-9150
DOIs	https://doi.org/10.1016/j.atherosclerosis.2015.07.031
Publication status	Published - Sept 2015

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10.1016/j.atherosclerosis.2015.07.031

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Dinh, K. M., Pedersen, O. B., Petersen, M. S., Sørensen, E., Sørensen, C. J., Kaspersen, K. A., Larsen, M. H., Møller, B., Hjalgrim, H., Ullum, H., & Erikstrup, C. (2015). The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study. Atherosclerosis, 242(1), 222-5. https://doi.org/10.1016/j.atherosclerosis.2015.07.031

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title = "The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study",

abstract = "BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.",

author = "Dinh, {Khoa M} and Pedersen, {Ole B} and Petersen, {Mikkel S} and Erik S{\o}rensen and S{\o}rensen, {Cecilie J} and Kaspersen, {Kathrine A} and Larsen, {Margit H} and Bjarne M{\o}ller and Henrik Hjalgrim and Henrik Ullum and Christian Erikstrup",

year = "2015",

month = sep,

doi = "10.1016/j.atherosclerosis.2015.07.031",

language = "English",

volume = "242",

pages = "222--5",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd.",

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}

Dinh, KM, Pedersen, OB, Petersen, MS, Sørensen, E, Sørensen, CJ , Kaspersen, KA, Larsen, MH, Møller, B, Hjalgrim, H, Ullum, H & Erikstrup, C 2015, 'The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study', Atherosclerosis, vol. 242, no. 1, pp. 222-5. https://doi.org/10.1016/j.atherosclerosis.2015.07.031

The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study. / Dinh, Khoa M; Pedersen, Ole B; Petersen, Mikkel S et al.
In: Atherosclerosis, Vol. 242, No. 1, 09.2015, p. 222-5.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease

T2 - Results from the Danish Blood Donor Study

AU - Dinh, Khoa M

AU - Pedersen, Ole B

AU - Petersen, Mikkel S

AU - Sørensen, Erik

AU - Sørensen, Cecilie J

AU - Kaspersen, Kathrine A

AU - Larsen, Margit H

AU - Møller, Bjarne

AU - Hjalgrim, Henrik

AU - Ullum, Henrik

AU - Erikstrup, Christian

PY - 2015/9

Y1 - 2015/9

N2 - BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

AB - BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

U2 - 10.1016/j.atherosclerosis.2015.07.031

DO - 10.1016/j.atherosclerosis.2015.07.031

M3 - Journal article

C2 - 26222902

SN - 0021-9150

VL - 242

SP - 222

EP - 225

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

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