TY - JOUR
T1 - The IGF System and Aging
AU - Conover, Cheryl A.
AU - Oxvig, Claus
N1 - Publisher Copyright:
© 2024 The Author(s). Published by Oxford University Press on behalf of the Endocrine Society.
PY - 2025/4
Y1 - 2025/4
N2 - There is strong evidence that IGF signaling is involved in fundamental aspects of the aging process. However, the extracellular part of the IGF system is complex with various receptors, ligand effectors, high-affinity IGF-binding proteins, proteinases, and endogenous inhibitors that all, along with their biological context, must be considered. The IGF system components are evolutionarily conserved, underscoring the importance of understanding this system in physiology and pathophysiology. This review will briefly describe the different components of the IGF system and then discuss past and current literature regarding IGF and aging, with a focus on cellular senescence, model organisms of aging, centenarian genetics, and 3 age-related diseases - pulmonary fibrosis, Alzheimer disease, and macular degeneration - in appropriate murine models and in humans. Commonalities in mechanism suggest conditions where IGF system components may be disease drivers and potential targets in promoting healthy aging in humans.
AB - There is strong evidence that IGF signaling is involved in fundamental aspects of the aging process. However, the extracellular part of the IGF system is complex with various receptors, ligand effectors, high-affinity IGF-binding proteins, proteinases, and endogenous inhibitors that all, along with their biological context, must be considered. The IGF system components are evolutionarily conserved, underscoring the importance of understanding this system in physiology and pathophysiology. This review will briefly describe the different components of the IGF system and then discuss past and current literature regarding IGF and aging, with a focus on cellular senescence, model organisms of aging, centenarian genetics, and 3 age-related diseases - pulmonary fibrosis, Alzheimer disease, and macular degeneration - in appropriate murine models and in humans. Commonalities in mechanism suggest conditions where IGF system components may be disease drivers and potential targets in promoting healthy aging in humans.
KW - age-related macular degeneration
KW - aging
KW - Alzheimer's disease
KW - insulin-like growth factors
KW - pulmonary fibrosis
UR - https://www.scopus.com/pages/publications/105000971405
U2 - 10.1210/endrev/bnae029
DO - 10.1210/endrev/bnae029
M3 - Review
C2 - 39418083
AN - SCOPUS:105000971405
SN - 0163-769X
VL - 46
SP - 214
EP - 223
JO - Endocrine Reviews
JF - Endocrine Reviews
IS - 2
ER -