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The house spider genome reveals an ancient whole-genome duplication during arachnid evolution
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DOI
- https://doi.org/10.1186/s12915-017-0399-x
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- Evelyn E. Schwager, Univ Massachusetts, University of Massachusetts Amherst, University of Massachusetts System, Dept Biostat & Epidemiol ,
- Prashant P. Sharma, University of Wisconsin-Milwaukee ,
- Thomas Clarke, J. Craig Venter Institute ,
- Daniel J. Leite, Oxford Brookes University ,
- Torsten Wierschin, Ernst Moritz Arndt Univ Greifswald, Ernst Moritz Arndt Universitat Greifswald, Bacterial Physiol, Inst Microbiol ,
- Matthias Pechmann, University of Cologne ,
- Yasuko Akiyama-Oda, Osaka Medical College ,
- Lauren Esposito, Calif Acad Sci ,
- Jesper Bechsgaard ,
- Trine Bilde
- Alexandra D. Buffry, Oxford Brookes University ,
- Hsu Chao, Baylor College of Medicine ,
- Huyen Dinh, Baylor College of Medicine ,
- HarshaVardhan Doddapaneni, Baylor College of Medicine ,
- Shannon Dugan, Baylor College of Medicine ,
- Cornelius Eibner, Friedrich Schiller University Jena ,
- Cassandra G. Extavour, Harvard University ,
- Peter Funch
- Jessica Garb, Univ Massachusetts, University of Massachusetts Amherst, University of Massachusetts System, Dept Biostat & Epidemiol ,
- Luis B. Gonzalez, Oxford Brookes University ,
- Vanessa L. Gonzalez, Smithsonian Institution, Washington D.C. ,
- Sam Griffiths-Jones, University of Manchester ,
- Yi Han, Baylor College of Medicine ,
- Cheryl Hayashi, Amer Museum Nat Hist, American Museum of Natural History (AMNH), Div Anthropol ,
- Maarten Hilbrant, University of Cologne ,
- Daniel S. T. Hughes, Baylor College of Medicine ,
- Ralf Janssen, Uppsala University ,
- Sandra L. Lee, Baylor College of Medicine ,
- Ignacio Maeso, Consejo Superior de Investigaciones Cientificas (CSIC) ,
- Shwetha C. Murali, Baylor College of Medicine ,
- Donna M. Muzny, Baylor College of Medicine ,
- Rodrigo Nunes da Fonseca, Universidade Federal do Rio de Janeiro ,
- Christian L. B. Paese, Oxford Brookes University ,
- Jiaxin Qu, Baylor College of Medicine ,
- Matthew Ronshaugen, University of Manchester ,
- Christoph Schomburg, Univ Gottingen, University of Gottingen, Inst Astrophys ,
- Anna Schonauer, Oxford Brookes University ,
- Angelika Stollewerk, University College London ,
- Montserrat Torres-Oliva, Univ Gottingen, University of Gottingen, Inst Astrophys ,
- Natascha Turetzek, Univ Gottingen, University of Gottingen, Inst Astrophys ,
- Bram Vanthournout ,
- John H. Werren, University of Rochester ,
- Carsten Wolff, Humboldt University of Berlin ,
- Kim C. Worley, Baylor College of Medicine ,
- Gregor Bucher, Georg August Univ ,
- Richard A. Gibbs, Baylor College of Medicine ,
- Jonathan Coddington, Smithsonian Institution, Washington D.C. ,
- Hiroki Oda, Osaka University ,
- Mario Stanke, Ernst Moritz Arndt Univ Greifswald, Ernst Moritz Arndt Universitat Greifswald, Bacterial Physiol, Inst Microbiol ,
- Nadia A. Ayoub, Washington & Lee Univ ,
- Nikola-Michael Prpic, Univ Gottingen, University of Gottingen, Inst Astrophys ,
- Jean-Francois Flot, Université Libre de Bruxelles ,
- Nico Posnien, Univ Gottingen, University of Gottingen, Inst Astrophys ,
- Stephen Richards, Baylor College of Medicine ,
- Alistair P. McGregor, Oxford Brookes University
Background: The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum.
Results: We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication.
Conclusions: Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes.
| Original language | English |
|---|---|
| Article number | 62 |
| Journal | B M C Biology |
| Volume | 15 |
| Number of pages | 27 |
| ISSN | 1741-7007 |
| DOIs | |
| Publication status | Published - 31 Jul 2017 |
- Parasteatoda tepidariorum, Genome, Centruroides sculpturatus, Gene duplication, Evolution, Hox genes, MESOBUTHUS-MARTENSII REVEALS, HOX GENES, PARASTEATODA-TEPIDARIORUM, PHYLOGENETIC ANALYSES, CUPIENNIUS-SALEI, HOMEOBOX GENES, ACHAEARANEA-TEPIDARIORUM, DEVELOPMENTAL BIOLOGY, EXPRESSION PATTERNS, DOSAGE-SENSITIVITY
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