The function of glycine decarboxylase complex is optimized to maintain high photorespiratory flux via buffering of its reaction products

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  • Natalia V Bykova, Cereal Research Centre, Agriculture and Agri-Food Canada, Canada
  • Ian Max Møller
  • Per Gardeström, Department of Plant Physiology, Umeå Plant Science Centre, University of Umeå, Sweden
  • Abir U Igamberdiev, Department of Biology, Memorial University of Newfoundland, Canada
Oxidation of glycine in photorespiratory pathway is the major flux through mitochondria of C3 plants in the light. It sustains increased intramitochondrial concentrations of NADH and NADPH, which are required to engage the internal rotenone-insensitive NAD(P)H dehydrogenases and the alternative oxidase. We discuss here possible mechanisms of high photorespiratory flux maintenance in mitochondria and suggest that it is fulfilled under conditions where the concentrations of glycine decarboxylase reaction products NADH and CO2 achieve an equilibrium provided by malate dehydrogenase and carbonic anhydrase, respectively. This results in the removal of these products from the glycine decarboxylase multienzyme active sites and in the maintenance of their concentrations at levels sufficiently low to prevent substrate inhibition of the reaction.
Original languageEnglish
JournalMitochondrion
Volume19
IssueB
Pages (from-to)357-364
Number of pages8
ISSN1567-7249
DOIs
Publication statusPublished - Nov 2014

    Research areas

  • Glycine decarboxylase, Non-coupled electron transport, Malate dehydrogenase, Carbonic anhydrase, Photorespiration

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