The female protective effect against autism spectrum disorder

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The female protective effect against autism spectrum disorder. / Wigdor, Emilie M; Weiner, Daniel J; Grove, Jakob et al.

In: Cell Genomics, Vol. 2, No. 6, 100134, 06.2022.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Wigdor, EM, Weiner, DJ, Grove, J, Fu, JM, Thompson, WK, Carey, CE, Baya, N, van der Merwe, C, Walters, RK, Satterstrom, FK, Palmer, DS, Rosengren, A, Bybjerg-Grauholm, J, Hougaard, DM, Mortensen, PB, Daly, MJ, Talkowski, ME, Sanders, SJ, Bishop, SL, Børglum, AD, Robinson, EB & iPSYCH Consortium 2022, 'The female protective effect against autism spectrum disorder', Cell Genomics, vol. 2, no. 6, 100134. https://doi.org/10.1016/j.xgen.2022.100134

APA

Wigdor, E. M., Weiner, D. J., Grove, J., Fu, J. M., Thompson, W. K., Carey, C. E., Baya, N., van der Merwe, C., Walters, R. K., Satterstrom, F. K., Palmer, D. S., Rosengren, A., Bybjerg-Grauholm, J., Hougaard, D. M., Mortensen, P. B., Daly, M. J., Talkowski, M. E., Sanders, S. J., Bishop, S. L., ... iPSYCH Consortium (2022). The female protective effect against autism spectrum disorder. Cell Genomics, 2(6), [100134]. https://doi.org/10.1016/j.xgen.2022.100134

CBE

Wigdor EM, Weiner DJ, Grove J, Fu JM, Thompson WK, Carey CE, Baya N, van der Merwe C, Walters RK, Satterstrom FK, et al. 2022. The female protective effect against autism spectrum disorder. Cell Genomics. 2(6):Article 100134. https://doi.org/10.1016/j.xgen.2022.100134

MLA

Wigdor, Emilie M et al. "The female protective effect against autism spectrum disorder". Cell Genomics. 2022. 2(6). https://doi.org/10.1016/j.xgen.2022.100134

Vancouver

Wigdor EM, Weiner DJ, Grove J, Fu JM, Thompson WK, Carey CE et al. The female protective effect against autism spectrum disorder. Cell Genomics. 2022 Jun;2(6):100134. doi: 10.1016/j.xgen.2022.100134

Author

Wigdor, Emilie M ; Weiner, Daniel J ; Grove, Jakob et al. / The female protective effect against autism spectrum disorder. In: Cell Genomics. 2022 ; Vol. 2, No. 6.

Bibtex

@article{1f7cb11c8442409dbaf088d6570267c8,

title = "The female protective effect against autism spectrum disorder",

abstract = "Autism spectrum disorder (ASD) is diagnosed three to four times more frequently in males than in females. Genetic studies of rare variants support a female protective effect (FPE) against ASD. However, sex differences in common inherited genetic risk for ASD are less studied, particularly within families. Leveraging the Danish iPSYCH resource, we found siblings of female ASD cases (n = 1,707) had higher rates of ASD than siblings of male ASD cases (n = 6,270; p < 1.0 × 10-10). In the Simons Simplex and SPARK collections, mothers of ASD cases (n = 7,436) carried more polygenic risk for ASD than fathers of ASD cases (n = 5,926; 0.08 polygenic risk score [PRS] SD; p = 7.0 × 10-7). Further, male unaffected siblings under-inherited polygenic risk (n = 1,519; p = 0.03). Using both epidemiologic and genetic approaches, our findings strongly support an FPE against ASD's common inherited influences.",

author = "Wigdor, {Emilie M} and Weiner, {Daniel J} and Jakob Grove and Fu, {Jack M} and Thompson, {Wesley K} and Carey, {Caitlin E} and Nikolas Baya and {van der Merwe}, Celia and Walters, {Raymond K} and Satterstrom, {F Kyle} and Palmer, {Duncan S} and Anders Rosengren and Jonas Bybjerg-Grauholm and Hougaard, {David M} and Mortensen, {Preben Bo} and Daly, {Mark J} and Talkowski, {Michael E} and Sanders, {Stephan J} and Bishop, {Somer L} and B{\o}rglum, {Anders D} and Robinson, {Elise B} and {iPSYCH Consortium}",

note = "{\textcopyright} 2022 The Authors.",

year = "2022",

month = jun,

doi = "10.1016/j.xgen.2022.100134",

language = "English",

volume = "2",

journal = "Cell Genomics",

issn = "2666-979X",

publisher = "Cell Press",

number = "6",

}

RIS

TY - JOUR

T1 - The female protective effect against autism spectrum disorder

AU - Wigdor, Emilie M

AU - Weiner, Daniel J

AU - Grove, Jakob

AU - Fu, Jack M

AU - Thompson, Wesley K

AU - Carey, Caitlin E

AU - Baya, Nikolas

AU - van der Merwe, Celia

AU - Walters, Raymond K

AU - Satterstrom, F Kyle

AU - Palmer, Duncan S

AU - Rosengren, Anders

AU - Bybjerg-Grauholm, Jonas

AU - Hougaard, David M

AU - Mortensen, Preben Bo

AU - Daly, Mark J

AU - Talkowski, Michael E

AU - Sanders, Stephan J

AU - Bishop, Somer L

AU - Børglum, Anders D

AU - Robinson, Elise B

AU - iPSYCH Consortium

PY - 2022/6

Y1 - 2022/6

N2 - Autism spectrum disorder (ASD) is diagnosed three to four times more frequently in males than in females. Genetic studies of rare variants support a female protective effect (FPE) against ASD. However, sex differences in common inherited genetic risk for ASD are less studied, particularly within families. Leveraging the Danish iPSYCH resource, we found siblings of female ASD cases (n = 1,707) had higher rates of ASD than siblings of male ASD cases (n = 6,270; p < 1.0 × 10-10). In the Simons Simplex and SPARK collections, mothers of ASD cases (n = 7,436) carried more polygenic risk for ASD than fathers of ASD cases (n = 5,926; 0.08 polygenic risk score [PRS] SD; p = 7.0 × 10-7). Further, male unaffected siblings under-inherited polygenic risk (n = 1,519; p = 0.03). Using both epidemiologic and genetic approaches, our findings strongly support an FPE against ASD's common inherited influences.

AB - Autism spectrum disorder (ASD) is diagnosed three to four times more frequently in males than in females. Genetic studies of rare variants support a female protective effect (FPE) against ASD. However, sex differences in common inherited genetic risk for ASD are less studied, particularly within families. Leveraging the Danish iPSYCH resource, we found siblings of female ASD cases (n = 1,707) had higher rates of ASD than siblings of male ASD cases (n = 6,270; p < 1.0 × 10-10). In the Simons Simplex and SPARK collections, mothers of ASD cases (n = 7,436) carried more polygenic risk for ASD than fathers of ASD cases (n = 5,926; 0.08 polygenic risk score [PRS] SD; p = 7.0 × 10-7). Further, male unaffected siblings under-inherited polygenic risk (n = 1,519; p = 0.03). Using both epidemiologic and genetic approaches, our findings strongly support an FPE against ASD's common inherited influences.

U2 - 10.1016/j.xgen.2022.100134

DO - 10.1016/j.xgen.2022.100134

M3 - Journal article

C2 - 36778135

VL - 2

JO - Cell Genomics

JF - Cell Genomics

SN - 2666-979X

IS - 6

M1 - 100134

ER -

Department of Economics and Business Economics